The dual role of tissue regulatory T cells in tissue repair: return to homeostasis or fibrosis

被引：1

作者：

Zhang, Peiyan

Wang, Jiawei

Miao, Jinlin ^{[1
]}

Zhu, Ping ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Xijing Hosp, Natl Translat Sci Ctr Mol Med, Dept Clin Immunol, Xian, Shaanxi, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2025年 / 16卷

关键词：

tissue regulatory T cells; tissue repair; fibrosis; immune cells; non-immune cells; HEPATIC STELLATE CELLS; NATURAL-KILLER; TGF-BETA; SKIN; INFLAMMATION; DIFFERENTIATION; AMPHIREGULIN; ACTIVATION; PROLIFERATION; EXPRESSION;

D O I：

10.3389/fimmu.2025.1560578

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tissue resident regulatory T cells (tissue Tregs) are vital for maintaining immune homeostasis and controlling inflammation. They aid in repairing damaged tissues and influencing the progression of fibrosis. However, despite extensive research on how tissue Tregs interact with immune and non-immune cells during tissue repair, their pro- and anti-fibrotic effects in chronic tissue injury remain unclear. Understanding how tissue Tregs interact with various cell types, as well as their roles in chronic injury and fibrosis, is crucial for uncovering the mechanisms behind these conditions. In this review, we describe the roles of tissue Tregs in repair and fibrosis across different tissues and explore potential strategies for regulating tissue homeostasis. These insights hold promise for providing new perspectives and approaches for the treatment of irreversible fibrotic diseases.

引用

页数：17

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