Minimally invasive robotic ureteral reconstruction using endoscopic submucosal dissection harvested colorectal mucosa graft for ureteral stricture

被引：0

作者：

Haihang Nie ^{[1
]}

Yali Yu ^{[2
]}

Xiubing Chen ^{[3
]}

Jingkai Zhou ^{[1
]}

Xianglin Li ^{[2
]}

Yuntian Hong ^{[3
]}

Fan Wang ^{[4
]}

Chaoqi Liang ^{[1
]}

Bing Li ^{[2
]}

Haizhou Wang ^{[3
]}

Hongling Wang ^{[1
]}

Qiu Zhao ^{[5
]}

Jiayan Nie ^{[1
]}

机构：

[1] Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan

[2] Hubei Provincial Clinical Research Center for Intestinal and Colorectal Diseases, Wuhan

[3] Hubei Key Laboratory of Intestinal and Colorectal Diseases, Zhongnan Hospital of Wuhan University, Wuhan

[4] Department of Gastroenterology, the Fifth Affiliated Hospital of Guangxi Medical University, Nanning

[5] Digestive Endoscopy Center, Zhongnan Hospital of Wuhan University, Wuhan

[6] Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan

[7] Institute of Urology, Wuhan University, Wuhan

来源：

Scientific Reports | / 15卷 / 1期

基金：

中国国家自然科学基金;

关键词：

Colorectal mucosa graft; Endoscopic submucosal dissection; Ureteral reconstruction; Ureteral stricture;

D O I：

10.1038/s41598-025-97826-2

中图分类号：

学科分类号：

摘要：

To evaluate the feasibility and safety of using colorectal mucosal grafts (CMG) harvested via endoscopic submucosal dissection (ESD) for ureteral reconstruction in patients with ureteral stricture. Eight patients with ureteral stricture underwent robotic ureteral reconstruction using CMG harvested by ESD. Preoperative assessments included clinical history, physical examination, and various imaging studies. The ESD procedure was performed with standard precautions to obtain sufficient graft material. Postoperative follow-up involved endoscopic examinations and retrograde pyelograms to assess colorectal complication and ureteral patency. The average age of patients was 44 years, and the median BMI was 24.6 kg/m². The causes of stricture included ureteral stones, urinary tract infections, and ureteral polyps. The median stricture length was 3.5 cm. The average size of the harvested CMG was 4 × 2.4 cm. The success rate of the grafting procedure was 100%, with no gastrointestinal complications observed. Endoscopic examination one week postoperatively revealed well-healed wounds. No recurrent ureteral strictures were noted during a median follow-up period of 5 months. The average glomerular filtration rate (GFR) of the affected kidneys was 61 ml/min. Harvesting CMG via ESD for ureteral reconstruction is feasible and safe, with minimal complications and promising short-term outcomes. This technique provides a viable alternative for patients contraindicated for oral mucosal grafts, potentially reducing morbidity associated with traditional intestinal mucosa harvesting methods. © The Author(s) 2025.

引用

共 11 条

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