Hepatitis C virus infection increases risk of peripheral arterial disease in end-stage renal disease patients receiving maintenance hemodialysis therapy

被引：0

作者：

Wang, Chih-Wen ^{[1
,2
,3
]}

Chen, Szu-Chia ^{[2
,3
,4
]}

Huang, Chung-Feng ^{[1
,3
]}

Su, Ho-Ming ^{[2
,3
,5
]}

Huang, Jiun-Chi ^{[2
,3
,4
]}

Wu, Pei-Yu ^{[2
,3
,4
]}

Yeh, Ming-Lun ^{[1
,3
]}

Lee, Pei-Lun ^{[6
]}

Dai, Chia-Yen ^{[1
,3
,7
]}

Huang, Jee-Fu ^{[1
,3
,7
,8
]}

Yu, Ming-Lung ^{[1
,3
,8
]}

Chuang, Wan-Long ^{[1
,3
]}

机构：

[1] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Hepatobiliary Div, 100 Tzyou 1st Rd, Kaohsiung 807, Taiwan

[2] Kaohsiung Med Univ, Kaohsiung Municipal Siaogang Hosp, Dept Internal Med, Kaohsiung, Taiwan

[3] Kaohsiung Med Univ, Coll Med, Fac Internal Med, Kaohsiung, Taiwan

[4] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung, Taiwan

[5] Kaohsiung Med Univ Hosp, Dept Internal Med, Div Cardiol, Kaohsiung, Taiwan

[6] Chi Mei Med Ctr, Dept Internal Med, Liouying Div Gastroenterol & Hepatol, Tainan, Taiwan

[7] Kaohsiung Med Univ, Grad Inst Clin Med, Kaohsiung, Taiwan

[8] Natl Sun Yat Sen Univ, Ctr Excellence Metab Associated Fatty Liver Dis, Kaohsiung, Taiwan

来源：

ADVANCES IN DIGESTIVE MEDICINE | 2024年

关键词：

baPWV; end-stage renal disease; HCV; peripheral arterial disease; PULSE-WAVE VELOCITY; ANKLE-BRACHIAL INDEX; CHRONIC KIDNEY-DISEASE; CHRONIC HCV INFECTION; CARDIOVASCULAR RISK; ASSOCIATION; STIFFNESS; ATHEROSCLEROSIS; MORTALITY; FIBROSIS;

D O I：

10.1002/aid2.13432

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Both hepatitis C virus (HCV) infection and end-stage renal disease are associated with an increased risk of developing peripheral arterial disease (PAD). Our objective was to explore the relationship between HCV infection and PAD in hemodialysis patients, using brachial-ankle pulse wave velocity (baPWV) as the assessment method. Since 2016, we have actively been recruiting patients undergoing regular hemodialysis three times a week. All baPWV assessments for our patients were performed before the implementation of direct-acting antiviral treatment. Furthermore, none of the uremic patients with HCV infection had received interferon-based treatment in the past. An elevated baPWV measurement surpassing 2100 cm/s is indicative of an increased susceptibility to potential PAD. Our analysis utilized multivariate linear and logistic regression analysis. Individuals with HCV infection exhibited higher baPWV levels compared with those without HCV infection (2006.0 +/- 687.4 vs. 1809.3 +/- 466.1 cm/s, p = .039). The presence of HCV infection (beta = 199.56, 95% CI: 10.56-388.56, p = .039) demonstrated a significantly positive correlation with baPWV levels. In the multivariate logistic regression analysis, HCV infection (OR = 2.67, 95% CI: 1.07-6.68, p = .036) significantly associated with baPWV >2100 cm/s. Furthermore, individuals with a higher viral load (HCV RNA >= 60 x 10(3) IU/mL) (OR = 4.45, 95% CI: 1.12-17.68, p = .034) demonstrated a significant association with baPWV >= 2100 cm/s when compared with non-HCV infection patients. Additionally, patients with genotype I exhibited a significant association with baPWV >= 2100 cm/s (OR = 8.13, 95% CI: 2.04-32.42, p = .003) in comparison to non-HCV patients. The presence of HCV infection has been demonstrated to markedly increase baPWV levels. Particularly, HCV infection with higher viral load and genotype I is significantly linked to an elevated risk of PAD. It emphasizes the importance of HCV elimination in the specific population.

引用

页数：12