HPV-16-Induced Squamous Cell Carcinoma in Hidradenitis Suppurativa: HPV Vaccination May Be Useful

被引：0

作者：

Abu Rached, Nessr ^{[1
,2
]}

Kaepynen, Riina ^{[1
,2
]}

Doerler, Martin ^{[1
,2
]}

Ocker, Lennart ^{[1
,2
]}

Frost, Carolin ^{[1
,2
]}

Haven, Yannik ^{[1
,2
]}

Bechara, Falk G. ^{[1
,2
]}

机构：

[1] Ruhr Univ Bochum, Int Ctr Hidradenitis Suppurat Acne Inversa ICH, Dept Dermatol Venereol & Allergol, D-44791 Bochum, Germany

[2] Ruhr Univ Bochum, Skin Canc Ctr, Dept Dermatol Venereol & Allergol, D-44791 Bochum, Germany

来源：

CANCERS | 2025年 / 17卷 / 04期

关键词：

hidradenitis suppurativa (HS); acne inversa; malignoma; squamous cell carcinoma; HPV; INFECTION; PREVENTION; CANCER; MEN; SEX;

D O I：

10.3390/cancers17040702

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Introduction: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease associated with significant morbidity. Although cutaneous squamous cell carcinoma (cSCC) is a rare complication, it has serious consequences, particularly when associated with high-risk human papillomavirus (HPV) infections. This study examines two cases of HPV-16-induced cSCC in patients with long-standing HS and explores the potential role of HPV vaccination in preventing such malignancies. Methods and results: We report on two male patients with severe HS (Hurley stage III) and cutaneous squamous cell carcinoma with positive detection of HPV DNA in the tumour tissue. Conclusions: HPV vaccination may offer a preventive approach to cSCC in HS patients by reducing high-risk HPV infections. Incorporating vaccination into the management of HS, particularly in high-risk individuals, could potentially reduce the incidence of malignant transformation and improve long-term outcomes. Further research is warranted to validate these findings and refine prevention strategies.

引用

页数：7

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