Mechanistic studies of incorporation of activated Islatravir by HIV-1 reverse transcriptase mutants

被引：0
作者：
Zalenski, Nikita [1 ]
Suo, Zucai [1 ]
机构：
[1] Florida State Univ, Tallahassee, FL 32306 USA
来源：
JOURNAL OF BIOLOGICAL CHEMISTRY | 2024年 / 300卷 / 03期
关键词：
Islatravir; EFdA; NRTI; HIV-1; RT; 4'-ethynyl-2-fluoro-2'-deoxyadenosine;
D O I：
10.1016/j.jbc.2024.106057
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
1113
引用
收藏
页码：S164 / S164
页数：1
相关论文
共 50 条
[21]   Application of Molecular Docking for the Development of Improved HIV-1 Reverse Transcriptase Inhibitors [J].
Soltani, Arash ;
Hashemy, Seyed Isaac ;
Avval, Farnaz Zahedi ;
Rafatpanah, Houshang ;
Rezaee, Seyed Abdolrahim ;
Griffith, Renate ;
Mashkani, Baratali .
CURRENT COMPUTER-AIDED DRUG DESIGN, 2021, 17 (04) :538-549
[22]   Inhibitors from Natural Products to HIV-1 Reverse Transcriptase, Protease and Integrase [J].
Jiang, Y. ;
Ng, T. B. ;
Wang, C. R. ;
Zhang, D. ;
Cheng, Z. H. ;
Liu, Z. K. ;
Qiao, W. T. ;
Geng, Y. Q. ;
Li, N. ;
Liu, F. .
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2010, 10 (14) :1331-1344
[23]   The HIV-1 Nef Protein Enhances the Affinity of Reverse Transcriptase for RNA In Vitro [J].
CÉcile Fournier ;
Jean-Claude Cortay ;
Caroline Carbonnelle ;
Chantal Ehresmann ;
Roland Marquet ;
Pierre Boulanger .
Virus Genes, 2002, 25 :255-269
[24]   The HIV-1 Nef protein enhances the affinity of reverse transcriptase for RNA in vitro [J].
Fournier, C ;
Cortay, JC ;
Carbonnelle, C ;
Ehresmann, C ;
Marquet, R ;
Boulander, P .
VIRUS GENES, 2002, 25 (03) :255-269
[25]   Peptides as new inhibitors of HIV-1 reverse transcriptase and integrase [J].
de Soultrait, VR ;
Desjobert, C ;
Tarrago-Litvak, L .
CURRENT MEDICINAL CHEMISTRY, 2003, 10 (18) :1765-1778
[26]   Indolyl aryl sulphones as HIV-1 reverse transcriptase inhibitors: docking and 3D QSAR studies [J].
Ragno, Rino ;
Coluccia, Antonio ;
La Regina, Giuseppe ;
Silvestri, Romano .
EXPERT OPINION ON DRUG DISCOVERY, 2007, 2 (01) :87-114
[27]   Non-nucleoside inhibitors of HIV-1 reverse transcriptase [J].
Proudfoot, JR .
EXPERT OPINION ON THERAPEUTIC PATENTS, 1998, 8 (08) :971-982
[28]   Purification of untagged HIV-1 reverse transcriptase by affinity chromatography [J].
Lu, Meiqing ;
Ngo, Winnie ;
Mei, Ye ;
Munshi, Vandna ;
Burlein, Christine ;
Loughran, Marie H. ;
Williams, Peter D. ;
Hazuda, Dana J. ;
Miller, Michael D. ;
Grobler, Jay A. ;
Diamond, Tracy L. ;
Lai, Ming-Tain .
PROTEIN EXPRESSION AND PURIFICATION, 2010, 71 (02) :231-239
[29]   HIV-1 Reverse Transcriptase Dissociates during Strand Transfer [J].
Muchiri, John M. ;
Rigby, Sean T. ;
Nguyen, Laura A. ;
Kim, Baek ;
Bambara, Robert A. .
JOURNAL OF MOLECULAR BIOLOGY, 2011, 412 (03) :354-364
[30]   Thymidine Analogue Mutations with M184V Significantly Decrease Phenotypic Susceptibility of HIV-1 Subtype C Reverse Transcriptase to Islatravir [J].
Byun, Hyeonah ;
Papathanasopoulos, Maria Antonia ;
Steegen, Kim ;
Basson, Adriaan Erasmus .
VIRUSES-BASEL, 2024, 16 (12)
12345