Choice of Drug for Malaria Prevention During Pregnancy Does Not Affect Infant Serologic Responses to Plasmodium falciparum Erythrocyte Membrane Proteins 1

被引：0

作者：

Ouattara, Amed ^{[1
]}

Andronescu, Liana R. ^{[1
]}

Adams, Matthew ^{[1
]}

Sharma, Ankur ^{[1
]}

Nakajima, Rie ^{[2
]}

Jain, Aarti ^{[2
]}

Taghavian, Omid ^{[2
]}

Jasinskas, Algis ^{[2
]}

Felgner, Philip L. ^{[2
]}

Mathanga, Don P. ^{[3
]}

Chinkhumba, Jobiba ^{[3
]}

Laufer, Miriam K. ^{[1
]}

Travassos, Mark A. ^{[1
]}

机构：

[1] Univ Maryland, Ctr Vaccine Dev & Global Hlth, Sch Med, Malaria Res Program, Baltimore, MD 21201 USA

[2] Univ Calif Irvine, Vaccine Res & Dev Ctr, Sch Med, Dept Physiol & Biophys, Irvine, CA USA

[3] Kamuzu Univ Hlth Sci, Malaria Alert Ctr, Blantyre, Malawi

来源：

OPEN FORUM INFECTIOUS DISEASES | 2025年 / 12卷 / 02期

基金：

美国国家卫生研究院;

关键词：

chemoprophylaxis; dihydroartemisinin-piperaquine; infants; pfEMP1; sulfadoxine-pyrimethamine; ANTIBODIES;

D O I：

10.1093/ofid/ofaf037

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

While sulfadoxine-pyrimethamine has been the primary drug in intermittent preventive treatment in pregnancy, dihydroartemisinin-piperaquine (DP) is being considered as an alternative. DP may lead to lower antimalarial antibodies in the mother, resulting in higher risk of malaria in infancy. We probed cord blood sera collected from women enrolled in a clinical trial of sulfadoxine-pyrimethamine vs DP on a protein microarray containing diverse Plasmodium falciparum erythrocyte membrane proteins 1 to measure the impact of intermittent preventive treatment in pregnancy on proteins associated with malaria disease susceptibility. These results suggest that effective maternal malaria prevention may not alter the susceptibility of infants to malaria.

引用

页数：4

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