Global brain activity and its coupling with cerebrospinal fluid flow is related to tau pathology

被引：6

作者：

Han, Feng ^{[1
]}

Lee, Jiaqie ^{[1
]}

Chen, Xi ^{[1
,2
]}

Ziontz, Jacob ^{[1
]}

Ward, Tyler ^{[1
]}

Landau, Susan M. ^{[1
]}

Baker, Suzanne L. ^{[2
]}

Harrison, Theresa M. ^{[1
]}

Jagust, William J. ^{[1
,2
]}

机构：

[1] Univ Calif Berkeley, Dept Neurosci, Berkeley, CA USA

[2] Lawrence Berkeley Natl Lab, Dept Cellular & Tissue Imaging, Berkeley, CA USA

来源：

ALZHEIMERS & DEMENTIA | 2024年 / 20卷 / 12期

基金：

加拿大健康研究院; 美国国家卫生研究院;

关键词：

Alzheimer's disease pathology; brain atrophy; cerebrospinal fluid (CSF) flow; CSF dynamics-related clearance; global resting-state fMRI signal; tau deposition; GLYMPHATIC SYSTEM ACTIVITY; ALZHEIMERS-DISEASE; AMYLOID-BETA; PERIVASCULAR SPACE; IMAGE-ANALYSIS; HEART-RATE; FMRI; FLUCTUATIONS; PROPAGATION; CLEARANCE;

D O I：

10.1002/alz.14296

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

INTRODUCTION: Factors responsible for the deposition of pathological tau in the brain are incompletely understood. This study links macroscale tau deposition in the human brain to cerebrospinal fluid (CSF) flow dynamics using resting-state functional magnetic resonance imaging (rsfMRI). METHODS: Low-frequency (< 0.1 Hz) resting-state global brain activity is coupled with CSF flow and potentially reflects CSF dynamics-related clearance. We examined the correlation between rsfMRI measures of CSF inflow and global activity (gBOLD-CSF coupling) as a predictor, interacting with amyloid beta (A beta), of tau and cortical thickness (dependent variables) across Alzheimer's Disease Neuroimaging Initiative (ADNI) participants from cognitively unimpaired through mild cognitive impairment (MCI) and Alzheimer's disease (AD). RESULTS: Tau deposition in A beta+ participants, accompanied by cortical thinning and cognitive decline, is associated with decreased gBOLD-CSF coupling. Tau mediates the relationship between coupling and thickness. DISCUSSION: Findings suggest that resting-state global brain activity and CSF movements comodulate Alzheimer's tau deposition, presumably related to CSF clearance.

引用

页码：8541 / 8555

页数：15

共 75 条

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