Extracellular vesicles and preterm infant diseases

被引：0

作者：

Chen, Wenqain ^{[1
,2
,3
]}

Kongsomros, Supasek ^{[3
]}

Thorman, Alexander ^{[3
]}

Esfandiari, Leyla ^{[4
,5
]}

Morrow, Ardythe L. ^{[3
,5
,6
]}

Chutipongtanate, Somchai ^{[3
,5
]}

Newburg, David S. ^{[3
]}

机构：

[1] Fujian Med Univ, Fujian Matern & Child Hlth Hosp, Dept Neonatol, Fuzhou, Fujian, Peoples R China

[2] Fujian Med Univ, Coll Clin Med Obstet & Gynecol & Pediat, Fuzhou, Fujian, Peoples R China

[3] Univ Cincinnati, Dept Environm & Publ Hlth Sci, Div Epidemiol,Coll Med, MILCH & Novel Therapeut Lab, Cincinnati, OH 45267 USA

[4] Univ Cincinnati, Coll Engn, Dept Biomed Engn, Cincinnati, OH USA

[5] Univ Cincinnati, Extracellular Vesicle Working Grp, Coll Med, Cincinnati, OH 45267 USA

[6] Cincinnati Childrens Hosp Med Ctr, Dept Infect Dis, Cincinnati, OH USA

来源：

FRONTIERS IN PEDIATRICS | 2025年 / 13卷

关键词：

preterm infants; extracellular vesicles; diseases; biomarkers; therapeutics; MESENCHYMAL STEM-CELLS; BRONCHOPULMONARY DYSPLASIA; NECROTIZING ENTEROCOLITIS; INTRAVENTRICULAR HEMORRHAGE; THERAPEUTIC APPLICATIONS; PREMATURE-INFANTS; NATIONAL CAUSES; RISK-FACTORS; EXOSOMES; BRAIN;

D O I：

10.3389/fped.2025.1550115

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

With the continuous improvement in perinatal care, the number of viable preterm infants is gradually increasing, along with the rise in preterm-related diseases such as necrotizing enterocolitis, bronchopulmonary dysplasia, perinatal brain injury, retinopathy of prematurity, and sepsis. Due to the unique pathophysiology of preterm infants, diagnosing and treating these diseases has become particularly challenging, significantly affecting their survival rate and long-term quality of life. Extracellular vesicles (EVs), as key mediators of intercellular communication, play an important regulatory role in the pathophysiology of these diseases. Because of their biological characteristics, EVs could serve as biomarkers and potential therapeutic agents for preterm-related diseases. This review summarizes the biological properties of EVs, their relationship with preterm-related diseases, and their prospects for diagnosis and treatment. EVs face unique challenges and opportunities for clinical applications.

引用

页数：15

共 170 条

[1] DetectEV: A functional enzymatic assay to assess integrity and bioactivity of extracellular vesicles [J].

Adamo, Giorgia ;

Picciotto, Sabrina ;

Gargano, Paola ;

Paterna, Angela ;

Raccosta, Samuele ;

Rao, Estella ;

Romancino, Daniele Paolo ;

Ghersi, Giulio ;

Manno, Mauro ;

Salamone, Monica ;

Bongiovanni, Antonella .

JOURNAL OF EXTRACELLULAR VESICLES, 2025, 14 (01)

[2] Brain-derived neurotropic factor mediates neuroprotection of mesenchymal stem cell-derived extracellular vesicles against severe intraventricular hemorrhage in newborn rats [J].

Ahn, So Yoon ;

Sung, Dong Kyung ;

Kim, Young Eun ;

Sung, Sein ;

Chang, Yun Sil ;

Park, Won Soon .

STEM CELLS TRANSLATIONAL MEDICINE, 2021, 10 (03) :374-384

[3]

Ali A, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-87706-w

[4] The economic impact of prematurity and bronchopulmonary dysplasia [J].

Alvarez-Fuente, Maria ;

Arruza, Luis ;

Muro, Marta ;

Zozaya, Carlos ;

Avila, Alejandro ;

Lopez-Ortego, Paloma ;

Gonzalez-Armengod, Carmen ;

Torrent, Alba ;

Luis Gavilan, Jose ;

Jesus del Cerro, Maria .

EUROPEAN JOURNAL OF PEDIATRICS, 2017, 176 (12) :1587-1593

[5] Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury [J].

Arslan, Fatih ;

Lai, Ruenn Chai ;

Smeets, Mirjam B. ;

Akeroyd, Lars ;

Choo, Andre ;

Aguor, Eissa N. E. ;

Timmers, Leo ;

van Rijen, Harold V. ;

Doevendans, Pieter A. ;

Pasterkamp, Gerard ;

Lim, Sai Kiang ;

de Kleijn, Dominique P. .

STEM CELL RESEARCH, 2013, 10 (03) :301-312

[6] Microglia toxicity in preterm brain injury [J].

Baburamani, Ana A. ;

Supramaniam, Veena G. ;

Hagberg, Henrik ;

Mallard, Carina .

REPRODUCTIVE TOXICOLOGY, 2014, 48 :106-112

[7] Intraventricular hemorrhage in premature infants: Mechanism of disease [J].

Ballabh P. .

Pediatric Research, 2010, 67 (1) :1-8

[8] Identification of a novel mechanism of blood-brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles [J].

Balusu, Sriram ;

Van Wonterghem, Ellen ;

De Rycke, Riet ;

Raemdonck, Koen ;

Stremersch, Stephan ;

Gevaert, Kris ;

Brkic, Marjana ;

Demeestere, Delphine ;

Vanhooren, Valerie ;

Hendrix, An ;

Libert, Claude ;

Vandenbroucke, Roosmarijn E. .

EMBO MOLECULAR MEDICINE, 2016, 8 (10) :1162-1183

[9] A perspective on the isolation and characterization of extracellular vesicles from different biofluids [J].

Bano, Reshma ;

Ahmad, Farhan ;

Mohsin, Mohd .

RSC ADVANCES, 2021, 11 (32) :19598-19615

[10]

Bashinsky Alice L, 2017, N C Med J, V78, P124, DOI 10.18043/ncm.78.2.124

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