The role of short-chain fatty acid metabolism in the pathogenesis, diagnosis and treatment of cancer

被引：0
|
作者：
Hou, Maolin [1 ]
Yu, Qing-Qing [2 ]
Yang, Le [3 ]
Zhao, Haibo [4 ]
Jiang, Pei [2 ]
Qin, Lei [3 ]
Zhang, Qiujie [4 ]
机构：
[1] Siziwangqi Peoples Hosp, Dept Internal Med, Wulancabu, Peoples R China
[2] Jining 1 Peoples Hosp, Translat Pharmaceut Lab, Jining, Peoples R China
[3] Jining 1 Peoples Hosp, Dept Gastrointestinal Surg, Jining, Peoples R China
[4] Jining 1 Peoples Hosp, Dept Oncol, Jining, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2024年 / 14卷
关键词：
short-chain fatty acid; metabolism; cancer; pathogenesis; diagnosis; treatment; EPITHELIAL-MESENCHYMAL TRANSITION; HUMAN GASTRIC-CANCER; CELL-CYCLE ARREST; GUT MICROBIOTA; BUTYRATE; EXPRESSION; APOPTOSIS; RECEPTOR; PROLIFERATION; METHYLATION;
D O I：
10.3389/fonc.2024.1451045
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Short-chain fatty acids (SCFAs), which are saturated fatty acids consisting of six or fewer carbon atoms, have been found to be closely associated with the biological behavior of malignant tumors. This manuscript provides a comprehensive review on the role of SCFAs in regulating cell cycle, apoptosis, tumor angiogenesis, epithelial-mesenchymal transition, protein regulatory pathways, and histone regulation in promoting the development of malignant tumors. Furthermore, we discuss the potential therapeutic strategies targeting SCFAs for treating malignant tumors. This review offers a theoretical foundation for investigating the mechanisms by which SCFAs impact malignant tumors and provides insights into developing novel treatment targets.
引用
收藏
页数：7
相关论文
共 50 条
  • [21] Short-chain fatty acids in nonalcoholic fatty liver disease: New prospects for short-chain fatty acids as therapeutic targets
    Li, Xinyu
    He, Maozhang
    Yi, Xinrui
    Lu, Xuejin
    Zhu, Meizi
    Xue, Min
    Tang, Yunshu
    Zhu, Yaling
    HELIYON, 2024, 10 (05)
  • [22] Short-Chain Fatty Acids Induce Apoptosis in Colon Cancer Cells Associated with Changes to Intracellular Redox State and Glucose Metabolism
    Matthews, Geoffrey M.
    Howarth, Gordon S.
    Butler, Ross N.
    CHEMOTHERAPY, 2012, 58 (02) : 102 - 109
  • [23] Contributions of colon short-chain fatty acid receptors in energy homeostasis
    Kuwahara, Atsukazu
    FRONTIERS IN ENDOCRINOLOGY, 2014, 5
  • [24] Short-Chain Fatty Acids in the Metabolism of Heart Failure - Rethinking the Fat Stigma
    Palm, Constantin L.
    Nijholt, Kirsten T.
    Bakker, Barbara M.
    Westenbrink, B. Daan
    FRONTIERS IN CARDIOVASCULAR MEDICINE, 2022, 9
  • [25] The role of short-chain fatty acids in central nervous system diseases
    Dong, Yin
    Cui, Chun
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 2022, 477 (11) : 2595 - 2607
  • [26] Role of short-chain fatty acids in host physiology
    Liu, Mingyue
    Lu, Yubo
    Xue, Guoyu
    Han, Le
    Jia, Hanbing
    Wang, Zi
    Zhang, Jia
    Liu, Peng
    Yang, Chaojuan
    Zhou, Yingjie
    ANIMAL MODELS AND EXPERIMENTAL MEDICINE, 2024, 7 (05) : 641 - 652
  • [27] Modulation of Adipocyte Metabolism by Microbial Short-Chain Fatty Acids
    May, Karolline S.
    den Hartigh, Laura J.
    NUTRIENTS, 2021, 13 (10)
  • [28] Short-chain fatty acids (SCFAs) from gastrointestinal disorders, metabolism, epigenetics, central nervous system to cancer - A mini-review
    Abdelhalim, Khalid A.
    CHEMICO-BIOLOGICAL INTERACTIONS, 2024, 388
  • [29] Microbial Short-Chain Fatty Acids and Blood Pressure Regulation
    Pluznick, Jennifer L.
    CURRENT HYPERTENSION REPORTS, 2017, 19 (04)
  • [30] Uptake and Metabolism of the Short-Chain Fatty Acid Butyrate, a Critical Review of the Literature
    Astbury, Stuart M.
    Corfe, Bernard M.
    CURRENT DRUG METABOLISM, 2012, 13 (06) : 815 - 821
12345