Stereotactic cardiac radiotherapy for refractory ventricular tachycardia in structural heart disease patients: a systematic review

被引:6
作者
Gupta, Amulya [1 ]
Sattar, Zeeshan [2 ]
Chaaban, Nourhan [3 ]
Ranka, Sagar [4 ]
Carlson, Cameron [5 ]
Sami, Farhad [6 ]
Robinson, Clifford G. [7 ]
Cuculich, Phillip S. [8 ]
Sheldon, Seth H. [1 ]
Reddy, Madhu [1 ]
Akhavan, David [9 ]
Noheria, Amit [1 ]
机构
[1] Univ Kansas Med Ctr, Dept Cardiovasc Med, 3901 Rainbow Blvd, Kansas City, KS 66160 USA
[2] Univ Kansas Med Ctr, Dept Gen & Hosp Med, Kansas City, KS USA
[3] Univ Kansas, Internal Med Dept, Sch Med, Wichita, KS USA
[4] Icahn Sch Med Mt Sinai, Div Cardiol, New York, NY USA
[5] Univ Denver, Nat Sci & Math, Denver, CO USA
[6] Univ Iowa, Div Cardiol, Iowa City, IA USA
[7] Washington Univ St Louis, Dept Radiat Oncol, St Louis, MO USA
[8] Washington Univ St Louis, Cardiovasc Div, St Louis, MO USA
[9] Univ Kansas Med Ctr, Dept Radiat Oncol, Kansas City, KS USA
来源
EUROPACE | 2025年 / 27卷 / 01期
关键词
Cardiac; Ventricular tachycardia; VT; Stereotactic body radiotherapy; SBRT; Stereotactic ablative body radiotherapy; SABR; Stereotactic arrhythmia radioablation; STAR; Radiotherapy; Radioablation; Meta-analysis; CATHETER ABLATION; RADIOABLATION; RADIATION; MORTALITY; TERM; RADIOSURGERY; THERAPY; SHOCKS;
D O I
10.1093/europace/euae305
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aims Among patients with structural heart disease with ventricular tachycardia (VT) refractory to medical therapy and catheter ablation, cardiac stereotactic body radiotherapy (SBRT) is a paradigm-changing treatment option. This study aims to assess the efficacy of cardiac SBRT in refractory VT by comparing the rates of VT episodes, anti-tachycardia pacing (ATP) therapies, and implantable cardioverter-defibrillator (ICD) shocks post-SBRT with pre-SBRT. Methods and results We performed a comprehensive literature search and included all clinical studies reporting outcomes on cardiac SBRT for VT. Treatment efficacy was evaluated as random-effects pooled rate-ratios of VT episodes, ATP therapies and ICD shocks post-SBRT (after 6-week blanking) and pre-SBRT, with patients serving as their own controls. Post-SBRT overall survival was assessed using Kaplan-Meier method. We included 23 studies published 2017-24 reporting on 225 patients who received cardiac SBRT, with median follow-up 5.8-28 months. There was significant heterogeneity among the studies for all three efficacy endpoints (P < 0.00001). The random-effects pooled rate-ratios of VT episodes, ATP therapies and ICD shocks post- vs. pre-SBRT were 0.10 (95% CI 0.06, 0.16), 0.09 (0.05, 0.15), and 0.09 (0.05, 0.17), respectively (all P < 0.00001). The most common reported complications included pericardial (8.0%, including 0.9% late oesophagogastro-pericardial fistula) and pulmonary (5.8%). There was no change in left ventricular ejection fraction post-SBRT (P = 0.3) but some studies reported an increase in mitral regurgitation. The combined 3-, 12-, and 24-month overall patient survival was 0.86 (0.80, 0.90), 0.72 (0.65, 0.78), and 0.57 (0.47, 0.67), respectively. Conclusion Among patients with refractory VT in context of structural heart disease, VT burden and ICD shocks are dramatically reduced following cardiac SBRT. The overall mortality in this population with heart failure and refractory VT receiving palliative cardiac SBRT remains high.
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页数:17
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