Exosome applications for the diagnosis and treatment of pancreatic ductal adenocarcinoma: An update (Review)

被引：1

作者：

Luan, Xinchi ^{[1
]}

Wang, Xuezhe ^{[1
]}

Bian, Gang ^{[2
]}

Li, Xiaoxuan ^{[3
]}

Gao, Ziru ^{[1
]}

Liu, Zijiao ^{[4
,5
]}

Zhang, Zhishang ^{[1
]}

Han, Tianyue ^{[1
]}

Zhao, Jinpeng ^{[1
]}

Zhao, Hongjiao ^{[1
]}

Luan, Xinyue ^{[1
]}

Zhu, Wuhui ^{[6
]}

Dong, Lili ^{[2
]}

Guo, Feifei ^{[1
]}

机构：

[1] Qingdao Univ, Sch Basic Med, Pathophysiol Dept, 308 Ningxia Rd, Qingdao 266071, Shandong, Peoples R China

[2] Qingdao Univ, Affiliated Qingdao Peoples Hosp 3, Dept Gastroenterol, 29 Yongping Rd, Qingdao 266041, Shandong, Peoples R China

[3] Qingdao Univ, Dept Oncol, Key Lab Canc Mol & Translat Res, Affiliated Hosp, Qingdao 266031, Shandong, Peoples R China

[4] Shandong First Med Univ & Shandong Acad Med Sci, Sch Clin & Basic Med, Jinan 250117, Shandong, Peoples R China

[5] Shandong First Med Univ & Shandong Acad Med Sci, Inst Basic Med, Jinan 250117, Shandong, Peoples R China

[6] Qingdao Univ, Affiliated Qingdao Peoples Hosp 3, Dept Hepatobiliary Surg, Qingdao 266041, Shandong, Peoples R China

来源：

ONCOLOGY REPORTS | 2025年 / 53卷 / 01期

关键词：

PDAC; biomarker; exosome; treatment; diagnosis; CELL-DERIVED EXOSOMES; MESENCHYMAL STROMAL CELLS; DRUG-DELIVERY SYSTEMS; CANCER-CELLS; IN-VITRO; EXTRACELLULAR VESICLES; TUMOR MICROBIOME; IMMUNE-ACTIVITY; GROWTH; KRAS;

D O I：

10.3892/or.2024.8846

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic ductal adenocarcinoma (PDAC) is a malignant neoplasm that typically manifests with subtle clinical manifestations in its early stages and frequently eludes diagnosis until the advanced phases of the disease. The limited therapeutic options available for PDAC significantly contribute to its high mortality rate, highlighting the urgent need for novel biomarkers capable of effectively identifying early clinical manifestations and facilitating precise diagnosis. The pivotal role of cellular exosomes in both the pathogenesis and therapeutic interventions for PDAC has been underscored. Furthermore, researchers have acknowledged the potential of exosomes as targeted drug carriers against regulatory cells in treating PDAC. The present article aims to provide a comprehensive review encompassing recent advancements in utilizing exosomes for elucidating mechanisms underlying disease development, patterns of metastasis, diagnostic techniques and treatment strategies associated with PDAC.

引用

页数：23

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