The Application of the Pyrazole Structure in the Structural Modification of Natural Products

被引：0

作者：

Sun, Fu-Qun ^{[1
]}

Wang, Ya-Lan ^{[1
]}

Sun, Ke ^{[1
]}

Yue, Fei-Xia ^{[1
]}

Sun, Yun-Xia ^{[1
]}

Ju, Jia-Hong ^{[1
]}

Jin, Zhan-Hui ^{[1
]}

Shen, Qing-Kun ^{[1
]}

Guo, Hong-Yan ^{[1
]}

Liu, Mei-Hui ^{[2
]}

Quan, Zhe-Shan ^{[1
]}

机构：

[1] Yanbian Univ, Coll Pharm, Key Lab Nat Med Changbai Mt, Minist Educ, Yanji 133002, Peoples R China

[2] Jiangsu Hlth Vocat Coll, Sch Pharm, Nanjing, Peoples R China

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2025年 / 25卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Pyrazole; natural products; structural modification; biological activity; CYTOTOXIC ACTIVITY EVALUATION; IN-VITRO; MOLECULAR DOCKING; AMYLOID-BETA; ANTIBACTERIAL ACTIVITY; BIOLOGICAL EVALUATION; ANTICANCER EVALUATION; ANTIVIRAL ACTIVITY; INHIBITORS DESIGN; ACID-DERIVATIVES;

D O I：

10.2174/0113895575359419241211092252

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Most natural products in nature have broad but not exceedingly good biological activities. The pyrazole structure has been introduced into natural products due to its suitability for various synthetic methods and its broad pharmacological activities. This article provides a detailed introduction to the anti-inflammatory, antibacterial, antifungal, antiviral, and anti-Alzheimer disease activities of pyrazole-modified natural product derivatives, particularly their anti-tumor activity. It is worth noting that compared to lead compounds, most natural product derivatives modified with pyrazole exhibit excellent pharmacological activity. Some of these derivatives exhibit outstanding anti-tumor activity, with IC50 values reaching nanomolar levels. This review provides more research directions and choices for future studies on natural products.

引用

页码：628 / 652

页数：25

共 125 条

[1] Synthesis of novel pyrazole derivatives and evaluation of their antidepressant and anticonvulsant activities [J].

Abdel-Aziz, Mohamed ;

Abuo-Rahma, Gamal El-Din A. ;

Hassan, Alaa A. .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (09) :3480-3487

[2] Design, synthesis, and molecular docking of novel pyrazole-chalcone analogs of lonazolac as 5-LOX, iNOS and tubulin polymerization inhibitors with potential anticancer and anti-inflammatory activities [J].

Ahmed, Asmaa H. H. ;

Mohamed, Mamdouh F. A. ;

Allam, Rasha M. ;

Nafady, Ayman ;

Mohamed, Shaaban K. ;

Gouda, Ahmed E. ;

Beshr, Eman A. M. .

BIOORGANIC CHEMISTRY, 2022, 129

[3] Sulfonamides containing curcumin scaffold: Synthesis, characterization, carbonic anhydrase inhibition and molecular docking studies [J].

Ahmed, Mahmood ;

Qadir, Muhammad Abdul ;

Hameed, Abdul ;

Arshad, Muhammad Nadeem ;

Asiri, Abdullah M. ;

Muddassar, Muhammad .

BIOORGANIC CHEMISTRY, 2018, 76 :218-227

[4] Screening of curcumin-derived isoxazole, pyrazoles, and pyrimidines for their anti-inflammatory, antinociceptive, and cyclooxygenase-2 inhibition [J].

Ahmed, Mahmood ;

Qadir, Muhammad Abdul ;

Hameed, Abdul ;

Imran, Muhammad ;

Muddassar, Muhammad .

CHEMICAL BIOLOGY & DRUG DESIGN, 2018, 91 (01) :338-343

[5] Synthesis and Antimicrobial Studies of Coumarin-Substituted Pyrazole Derivatives as Potent Anti-Staphylococcus aureusAgents [J].

Alnufaie, Rawan ;

Raj KC, Hansa ;

Alsup, Nickolas ;

Whitt, Jedidiah ;

Andrew Chambers, Steven ;

Gilmore, David ;

Alam, Mohammad A. .

MOLECULES, 2020, 25 (12)

[6] Design and synthesis of novel coumarin derivatives as potential acetylcholinesterase inhibitors for Alzheimer?s disease [J].

Amin, Kamilia M. ;

Rahman, Doaa E. Abdel ;

Allam, Heba Abdelrasheed ;

El-Zoheiry, Haidy H. .

BIOORGANIC CHEMISTRY, 2021, 110

[7] Synthesis and anticancer activity of some 8-substituted-7-methoxy-2H-chromen-2-one derivatives toward hepatocellular carcinoma HepG2 cells [J].

Amin, Kamilia M. ;

Abou-Seri, Sahar M. ;

Awadallah, Fadi M. ;

Eissa, Amal A. M. ;

Hassan, Ghaneya S. ;

Abdulla, Mohamed M. .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 90 :221-231

[8] Coumarinyl pyrazole derivatives of INH: promising antimycobacterial agents [J].

Aragade, Prashant ;

Palkar, Mahesh ;

Ronad, Pradeepkumar ;

Satyanarayana, Darbhamulla .

MEDICINAL CHEMISTRY RESEARCH, 2013, 22 (05) :2279-2283

[9] Microwave-assisted one-pot synthesis of some new flavonols by modified Algar-Flynn-Oyamada reaction and their antimicrobial activity [J].

Ashok, Dongamanti ;

Kifah, Mohsin Ahmed ;

Lakshmi, Bommidi Vijaya ;

Sarasija, Madderla ;

Adam, Shaik .

CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2016, 52 (03) :172-176

[10] Microwave-assisted synthesis, molecular docking and antimicrobial activity of novel 2-(3-aryl,1-phenyl-1H-pyrazol-4-yl)-8H-pyrano[2,3-f]chromen-4-ones [J].

Ashok, Dongamanti ;

Rangu, Kavitha ;

Rao, Velagapuri Hanumantha ;

Gundu, Srinivas ;

Srilata, Ballu ;

Vijjulatha, Manga .

MEDICINAL CHEMISTRY RESEARCH, 2016, 25 (03) :501-514

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