Pinitol Improves Diabetic Foot Ulcers in Streptozotocin-Induced Diabetes Rats Through Upregulation of Nrf2/HO-1 Signaling

被引：2

作者：

Kim, Jinsick ^{[1
]}

Go, Min Young ^{[1
]}

Jeon, Chae Young ^{[1
]}

Shin, Jung Un ^{[1
]}

Kim, Mujun ^{[1
]}

Lim, Hye Won ^{[1
]}

Shin, Dong Wook ^{[1
]}

机构：

[1] Konkuk Univ, Res Inst Biomed & Hlth Sci, Chungju 27478, South Korea

来源：

ANTIOXIDANTS | 2025年 / 14卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

pinitol; diabetic foot ulcers; streptozotocin; diabetic rat; Nrf2; NRF2; METFORMIN; MECHANISMS; MELLITUS; BURDEN; MODELS;

D O I：

10.3390/antiox14010015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Diabetic foot ulcers represent a severe complication of diabetes, often resulting in amputation and high mortality rates. Currently, there are no treatments for diabetic foot ulcers other than antibiotics and dressings. In this study, we evaluated the wound-healing effects of an antidiabetic agent pinitol in lipopolysaccharide (LPS)-damaged human dermal fibroblasts (HDFs) and streptozotocin (STZ)-induced diabetic rat models with a foot wound. Our findings indicated that pinitol enhanced cell migration, proliferation, and wound healing by activating Nrf2, thereby mitigating oxidative stress and inflammatory responses at the wound site. Additionally, pinitol restored mitochondrial energy metabolism, decreased matrix metalloproteinase (MMP) activity, and increased collagen deposition. Furthermore, pinitol facilitated angiogenesis, contributing to improved wound healing. Taken together, these findings suggest that pinitol could be a promising therapeutic agent for the treatment of diabetic foot ulcers.

引用

页数：19

共 53 条

[51] Artemisitene Alters LPS-Induced Oxidative stress, inflammation and Ferroptosis in Liver Through Nrf2/HO-1 and NF-kB Pathway [J].

Zhao, Changzhi ;

Xiao, Congshu ;

Feng, Songqiao ;

Bai, Jianxin .

FRONTIERS IN PHARMACOLOGY, 2023, 14

[52] Diabetes: a 21st century challenge [J].

Zimmet, Paul Z. ;

Magliano, Dianna J. ;

Herman, William H. ;

Shaw, Jonathan E. .

LANCET DIABETES & ENDOCRINOLOGY, 2014, 2 (01) :56-64

[53] Mitochondrial membrane potential [J].

Zorova, Ljubava D. ;

Popkov, Vasily A. ;

Plotnikov, Egor Y. ;

Silachev, Denis N. ;

Pevzner, Irina B. ;

Jankauskas, Stanislovas S. ;

Babenko, Valentina A. ;

Zorov, Savva D. ;

Balakireva, Anastasia V. ;

Juhaszova, Magdalena ;

Sollott, Steven J. ;

Zorov, Dmitry B. .

ANALYTICAL BIOCHEMISTRY, 2018, 552 :50-59

← 1 2 3 4 5 6 →