EVALUATION OF ANTI-INFLAMMATORY ACTIVITY AND CHEMICAL COMPOSITION OF FILIPENDULA VULGARIS MOENCH AND FILIPENDULA ULMARIA (L.) MAXIM EXTRACTS OBTAINED BY ULTRASONIC METHOD

Scientific interest in herbal medicines can be explained by their numerous advantages, including lower toxicity compared to synthetic analogues. Plants contain a wide variety of biologically active substances, which contributes to the diverse pharmacological effects of herbal medicines. In this context, the search for new types of medicinal plant materials is recognised as a crucial task. Additionally, developing new methods or enhancing existing technologies for intensifying the extraction of biologically valuable active substances from plants is a highly relevant goal in pharmaceutical science. In the composition of thick extracts, 16 phenolic compounds were identified and quantified using HPLC-MS, Aincluding 6 phenolic acids and 10 flavonoids. Our study investigated the anti-inflammatory and regenerative effects of herbal extracts derived from Filipendula vulgaris Moench and Filipendula ulmaria (L.) Maxim, collected in Central Kazakhstan, and obtained via ultrasound-assisted extraction. The anti-inflammatory effects of these thick extracts were evaluated using 2 models: the "formalin oedema" model to simulate acute exudative reactions and the "felt granuloma" model to assess chronic proliferative inflammation. The results, along with histological analyses of the samples, indicate that extracts of Filipendula vulgaris and Filipendula ulmaria exhibit significant anti-inflammatory and wound-healing properties. These findings highlight their potential for the development of domestic anti-inflammatory and wound-healing drugs.