Regulatory Mechanisms of Aging Through the Nutritional and Metabolic Control of Amino Acid Signaling in Model Organisms

被引：3

作者：

Obata, Fumiaki ^{[1
,2
]}

Miura, Masayuki ^{[3
]}

机构：

[1] RIKEN Ctr Biosyst Dynam Res, Lab Nutr Biol, Kobe, Hyogo, Japan

[2] Kyoto Univ, Grad Sch Biostudies, Lab Mol Cell Biol & Dev, Kyoto, Japan

[3] Univ Tokyo, Grad Sch Pharmaceut Sci, Dept Genet, Bunkyo Ku, Tokyo, Japan

来源：

ANNUAL REVIEW OF GENETICS | 2024年 / 58卷

基金：

日本学术振兴会;

关键词：

nutrition; metabolism; amino acid; aging; lifespan; genetic studies; LIFE-SPAN EXTENSION; DIETARY RESTRICTION; C; ELEGANS; CALORIC RESTRICTION; NORDIHYDROGUAIARETIC ACID; MITOCHONDRIAL BIOGENESIS; METHIONINE RESTRICTION; S-ADENOSYLMETHIONINE; GENE-EXPRESSION; SEX-DIFFERENCES;

D O I：

10.1146/annurev-genet-111523-102042

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Life activities are supported by the intricate metabolic network that is fueled by nutrients. Nutritional and genetic studies in model organisms have determined that dietary restriction and certain mutations in the insulin signaling pathway lead to lifespan extension. Subsequently, the detailed mechanisms of aging as well as various nutrient signaling pathways and their relationships have been investigated in a wide range of organisms, from yeast to mammals. This review summarizes the roles of nutritional and metabolic signaling in aging and lifespan with a focus on amino acids, the building blocks of organisms. We discuss how lifespan is affected by the sensing, transduction, and metabolism of specific amino acids and consider the influences of life stage, sex, and genetic background on the nutritional control of aging. Our goal is to enhance our understanding of how nutrients affect aging and thus contribute to the biology of aging and lifespan.

引用

页码：19 / 41

页数：23

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