Biomarkers in Psoriasis and Psoriatic Arthritis: Where Are We Now?

被引：3

作者：

Chandran, Vinod ^{[1
,2
,3
]}

Liao, Wilson ^{[4
]}

de Vlam, Kurt ^{[5
,6
]}

机构：

[1] Univ Toronto, Dept Med, Div Rheumatol, Toronto, ON, Canada

[2] Univ Toronto, Lab Med & Pathobiol, Toronto, ON, Canada

[3] Univ Hlth Network, Krembil Res Inst, Toronto, ON, Canada

[4] Univ Calif San Francisco, Dept Dermatol, San Francisco, CA USA

[5] Univ Hosp Leuven, Dept Rheumatol, Leuven, Belgium

[6] Katholieke Univ Leuven, Skeletal Biol & Engn Res Ctr SBE, Dept Dev & Regenerat, Leuven, Belgium

来源：

JOURNAL OF RHEUMATOLOGY | 2024年 / 51卷

关键词：

biomarkers; GRAPPA; precision medicine; psoriasis; psoriatic arthritis;

D O I：

10.3899/jrheum.2024-0260

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

At the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) 2023 annual conference and trainee symposium, the status of psoriatic disease (PsD) biomarkers was discussed in a workshop. The significant heterogeneity of PsD causes disease management to be very challenging, but biomarkers can prove helpful in disease diagnosis, stratification, and precision medicine. Although a few potential biomarkers have been discovered, none have been fully validated. Recent studies have used omic technologies that show promise but need further verification and validation. Many challenges remain, but the anticipated results of studies being conducted by recently established large consortia may lead to the identification of clinically actionable biomarkers.

引用

页码：74 / 76

页数：3

共 25 条

[1] Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework [J].

Atkinson, AJ ;

Colburn, WA ;

DeGruttola, VG ;

DeMets, DL ;

Downing, GJ ;

Hoth, DF ;

Oates, JA ;

Peck, CC ;

Schooley, RT ;

Spilker, BA ;

Woodcock, J ;

Zeger, SL .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 2001, 69 (03) :89-95

[2]

Burke Harry B, 2016, Biomark Cancer, V8, P89, DOI [10.4137/bic.s33380, 10.4137/BIC.S33380]

[3] Analysis of serum proteomics data identifies a quantitative association between beta-defensin 2 at baseline and clinical response to IL-17 blockade in psoriatic arthritis [J].

Cardner, Mathias ;

Tuckwell, Danny ;

Kostikova, Anna ;

Forrer, Pascal ;

Siegel, Richard M. ;

Marti, Alain ;

Vandemeulebroecke, Marc ;

Ferrero, Enrico .

RMD OPEN, 2023, 9 (02)

[4] Serum-based soluble markers differentiate psoriatic arthritis from osteoarthritis [J].

Chandran, Vinod ;

Abji, Fatima ;

Perruccio, Anthony V. ;

Gandhi, Rajiv ;

Li, Suzanne ;

Cook, Richard J. ;

Gladman, Dafna D. .

ANNALS OF THE RHEUMATIC DISEASES, 2019, 78 (06) :796-801

[5] HLA-C*06:02 genotype is a predictive biomarker of biologic treatment response in psoriasis [J].

Dand, Nick ;

Duckworth, Michael ;

Baudry, David ;

Russell, Alice ;

Curtis, Charles J. ;

Lee, Sang Hyuck ;

Evans, Ian ;

Mason, Kayleigh J. ;

Alsharqi, Ali ;

Becher, Gabrielle ;

Burden, A. David ;

Goodwin, Richard G. ;

McKenna, Kevin ;

Murphy, Ruth ;

Perera, Gayathri K. ;

Rotarescu, Radu ;

Wahie, Shyamal ;

Wright, Andrew ;

Reynolds, Nick J. ;

Warren, Richard B. ;

Griffiths, Christopher E. M. ;

Smith, Catherine H. ;

Simpson, Michael A. ;

Barker, Jonathan N. ;

Benham, Marilyn ;

Hussain, Sagair ;

Kirby, Brian ;

Lawson, Linda ;

McElhone, Kathleen ;

Ormerod, Anthony ;

Owen, Caroline ;

Barnes, Michael R. ;

Di Meglio, Paola ;

Emsley, Richard ;

Evans, Andrea ;

Payne, Katherine ;

Stocken, Deborah ;

Barker, Jonathan ;

Burden, David ;

Griffiths, Christopher ;

Mason, Kayleigh ;

Reynolds, Nick ;

Smith, Catherine ;

Warren, Richard .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2019, 143 (06) :2120-2130

[6] Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities [J].

Davis, Karen D. ;

Aghaeepour, Nima ;

Ahn, Andrew H. ;

Angst, Martin S. ;

Borsook, David ;

Brenton, Ashley ;

Burczynski, Michael E. ;

Crean, Christopher ;

Edwards, Robert ;

Gaudilliere, Brice ;

Hergenroeder, Georgene W. ;

Iadarola, Michael J. ;

Iyengar, Smriti ;

Jiang, Yunyun ;

Kong, Jiang-Ti ;

Mackey, Sean ;

Saab, Carl Y. ;

Sang, Christine N. ;

Scholz, Joachim ;

Segerdahl, Marta ;

Tracey, Irene ;

Veasley, Christin ;

Wang, Jing ;

Wager, Tor D. ;

Wasan, Ajay D. ;

Pelleymounter, Mary Ann .

NATURE REVIEWS NEUROLOGY, 2020, 16 (07) :381-400

[7] Defining imaging sub-phenotypes of psoriatic arthritis: integrative analysis of imaging data and gene expression in a PsA patient cohort [J].

Eder, Lihi ;

Li, Quan ;

Rahmati, Sara ;

Rahman, Proton ;

Jurisica, Igor ;

Chandran, Vinod .

RHEUMATOLOGY, 2022, 61 (12) :4952-4961

[8] HIPPOCRATES: improving diagnosis and outcomes in psoriatic arthritis [J].

FitzGerald, Oliver ;

Pennington, Stephen R. .

NATURE REVIEWS RHEUMATOLOGY, 2022, 18 (03) :123-124

[9] Natural History, Prognosis, and Socioeconomic Aspects of Psoriatic Arthritis [J].

Helliwell, Philip S. ;

Ruderman, Eric M. .

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA, 2015, 41 (04) :581-+

[10] Molecular biomarkers [J].

Laterza, Omar F. ;

Hendrickson, Ronald C. ;

Wagner, John A. .

DRUG INFORMATION JOURNAL, 2007, 41 (05) :573-585

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