Highly Sensitive Non-Enzymatic Electrochemical Sensor to Detect an Important Neurotransmitter Using Cobalt-Based Metal-Organic Framework/Graphene Oxide Composite

Glutamate (Glu) is a principal neurotransmitter owing to its significant function in physiological and pathological processes. Deviations in Glu levels have been associated with the onset of various neurological disorders, implicating it as a potential biomarker for conditions like epilepsy, stroke, Alzheimer's disease, and amyotrophic lateral sclerosis. Accurate detection of Glu is essential for the prevention, diagnosis, and treatment of such diseases. Herein, a highly sensitive non-enzymatic sensor is introduced to detect Glu. The electrochemical performance of Glu was studied by modifying the glassy carbon electrode using a cobalt-based metal-organic framework/graphene oxide composite (CoMG/GCE). Differential pulse voltammetry exhibited a linear response from 20.0 to 1.00 x 103 mu M at an alkali solution with a detection limit of 3.10 mu M. DPV was utilized to determine Glu in human blood serum samples using the standard addition method. This sensor showed the lowest interference with popular interference species, indicating its ability for healthcare applications.