Oxidative Stress and Cancer Therapy: Controlling Cancer Cells Using Reactive Oxygen Species

被引：9

作者：

Ju, Songhyun ^{[1
,2
,3
]}

Singh, Manish Kumar ^{[1
,2
]}

Han, Sunhee ^{[1
,2
,3
]}

Ranbhise, Jyotsna ^{[1
,2
,3
]}

Ha, Joohun ^{[1
,2
]}

Choe, Wonchae ^{[1
,2
]}

Yoon, Kyung-Sik ^{[1
,2
]}

Yeo, Seung Geun ^{[4
]}

Kim, Sung Soo ^{[1
,2
]}

Kang, Insug ^{[1
,2
]}

机构：

[1] Kyung Hee Univ, Sch Med, Dept Biochem & Mol Biol, Seoul 02447, South Korea

[2] Kyung Hee Univ, Biomed Sci Inst, Seoul 02447, South Korea

[3] Kyung Hee Univ, Grad Sch, Dept Biomed Sci, Seoul 02447, South Korea

[4] Kyung Hee Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Med Ctr, Seoul 02453, South Korea

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 22期

基金：

新加坡国家研究基金会;

关键词：

cancer; reactive oxygen species (ROS); oxidative stress; NF-KAPPA-B; ENDOPLASMIC-RETICULUM STRESS; GLYCOGEN-SYNTHASE KINASE-3; HYDROGEN-PEROXIDE; ER STRESS; TUMOR PROGRESSION; INDUCED APOPTOSIS; BREAST-CANCER; GROWTH-FACTOR; FREE-RADICALS;

D O I：

10.3390/ijms252212387

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer is a multifaceted disease influenced by various mechanisms, including the generation of reactive oxygen species (ROS), which have a paradoxical role in both promoting cancer progression and serving as targets for therapeutic interventions. At low concentrations, ROS serve as signaling agents that enhance cancer cell proliferation, migration, and resistance to drugs. However, at elevated levels, ROS induce oxidative stress, causing damage to biomolecules and leading to cell death. Cancer cells have developed mechanisms to manage ROS levels, including activating pathways such as NRF2, NF-kappa B, and PI3K/Akt. This review explores the relationship between ROS and cancer, focusing on cell death mechanisms like apoptosis, ferroptosis, and autophagy, highlighting the potential therapeutic strategies that exploit ROS to target cancer cells.

引用

页数：26

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