Association between imprinting disorders and assisted reproductive technologies

被引：0
作者：
Kagami, Masayo [1 ]
Hara-Isono, Kaori [1 ,2 ]
Sasaki, Aiko [3 ]
Amita, Mitsuyoshi [4 ]
机构：
[1] Natl Res Inst Child Hlth & Dev, Dept Mol Endocrinol, 2-10-1 Okura,Setagaya Ku, Tokyo 1578535, Japan
[2] Keio Univ, Sch Med, Dept Pediat, Tokyo, Japan
[3] Natl Ctr Child Hlth & Dev, Ctr Maternal Fetal Neonatal & Reprod Med, Div Obstet, Tokyo, Japan
[4] Natl Ctr Child Hlth & Dev, Div Reprod Med, Tokyo, Japan
来源：
EPIGENOMICS | 2025年 / 17卷 / 06期
关键词：
Assisted reproductive technologies; imprinting disorders; epimutation; DNA methylation; infertility; maternal childbearing age; IN-VITRO FERTILIZATION; GERMINAL VESICLE STAGE; PATERNAL ISODISOMY; DNA METHYLATION; TRANSPOSABLE ELEMENTS; EPIGENETIC CONTROL; CYSTIC-FIBROSIS; AMINO-ACIDS; CHROMOSOME-7; CULTURE;
D O I：
10.1080/17501911.2025.2471269
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Aberrant expression of imprinted genes results in imprinting disorders (IDs). Differentially methylated regions (DMRs) reveal parental-origin-specific DNA methylation on CpGs and regulate the expression of the imprinted genes. One etiology of IDs is epimutation (epi-IDs) induced by some error in the establishment or maintenance of methylation imprint during the processes of gametogenesis, fertilization, or early embryonic development. Therefore, it has been a concern that assisted reproductive technologies (ART) increase the risk for the development of IDs, particularly epi-IDs. We review the effects of ART on DNA methylation of the genome, including DMRs in gametes, embryos, and offspring, and the risk of advanced parental age (a confounding factor of ART) and infertility itself for the development of IDs, particularly epi-IDs.
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收藏
页码：397 / 410
页数：14
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