Macrophages in the Context of Muscle Regeneration and Duchenne Muscular Dystrophy

被引：3

作者：

Hernandez-Torres, Francisco ^{[1
,2
]}

Matias-Valiente, Lidia ^{[2
,3
]}

Alzas-Gomez, Virginia ^{[2
,3
]}

Aranega, Amelia Eva ^{[2
,3
]}

机构：

[1] Univ Granada, Fac Med, Dept Biochem & Mol Biol & Immunol 3, Granada 18016, Spain

[2] Medina Fdn, Technol Pk Hlth Sci, Granada 18016, Spain

[3] Univ Jaen, Fac Expt Sci, Dept Expt Biol, Jaen 23071, Spain

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 19期

关键词：

macrophages; inflammation; skeletal muscle; Duchenne muscular dystrophy; GLYCOGEN-SYNTHASE KINASE-3-BETA; TISSUE-RESIDENT MACROPHAGES; TUMOR-NECROSIS-FACTOR; QUALITY-OF-LIFE; GROWTH-FACTOR-I; SKELETAL-MUSCLE; SATELLITE CELLS; TNF-ALPHA; FIBRO/ADIPOGENIC PROGENITORS; DENDRITIC CELLS;

D O I：

10.3390/ijms251910393

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Macrophages are essential to muscle regeneration, as they regulate inflammation, carry out phagocytosis, and facilitate tissue repair. These cells exhibit phenotypic switching from pro-inflammatory (M1) to anti-inflammatory (M2) states during muscle repair, influencing myoblast proliferation, differentiation, and myofiber formation. In Duchenne Muscular Dystrophy (DMD), asynchronous muscle injuries disrupt the normal temporal stages of regeneration, leading to fibrosis and failed regeneration. Altered macrophage activity is associated with DMD progression and physiopathology. Gaining insight into the intricate relationship between macrophages and muscle cells is crucial for creating effective therapies aimed at treating this muscle disorder. This review explores the dynamic functions of macrophages in muscle regeneration and their implications in DMD.

引用

页数：22

共 170 条

[11]

Birnkrant DJ, 2018, LANCET NEUROL, V17, P251, DOI 10.1016/S1474-4422(18)30024-3

[12] Fibrin, Bone Marrow Cells and Macrophages Interactively Modulate Cardiomyoblast Fate [J].

Borrego, Ines ;

Frobert, Aurelien ;

Ajalbert, Guillaume ;

Valentin, Jeremy ;

Kaltenrieder, Cyrielle ;

Fellay, Benoit ;

Stumpe, Michael ;

Cook, Stephane ;

Dengjel, Joern ;

Giraud, Marie-Noelle .

BIOMEDICINES, 2022, 10 (03)

[13] Muscle Resident Macrophages Control the Immune Cell Reaction in a Mouse Model of Notexin-Induced Myoinjury [J].

Brigitte, Madly ;

Schilte, Clementine ;

Plonquet, Anne ;

Baba-Amer, Yasmine ;

Henri, Adeline ;

Charlier, Caroline ;

Tajbakhsh, Shahragim ;

Albert, Matthew ;

Gherardi, Romain K. ;

Chretien, Fabrice .

ARTHRITIS AND RHEUMATISM, 2010, 62 (01) :268-279

[14] Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival [J].

Buscher, Konrad ;

Ehinger, Erik ;

Gupta, Pritha ;

Pramod, Akula Bala ;

Wolf, Dennis ;

Tweet, George ;

Pan, Calvin ;

Mills, Charles D. ;

Lusis, Aldons J. ;

Ley, Klaus .

NATURE COMMUNICATIONS, 2017, 8

[15] A Review of Deflazacort for Patients With Duchenne Muscular Dystrophy [J].

Bylo, Mary ;

Farewell, Raechel ;

Coppenrath, Valerie A. ;

Yogaratnam, Dinesh .

ANNALS OF PHARMACOTHERAPY, 2020, 54 (08) :788-794

[16] Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy [J].

Cannarile, Michael A. ;

Weisser, Martin ;

Jacob, Wolfgang ;

Jegg, Anna-Maria ;

Ries, Carola H. ;

Ruettinger, Dominik .

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2017, 5

[17] Long-term clinical activity, safety and patient-reported quality of life for emactuzumab-treated patients with diffuse-type tenosynovial giant-cell tumour [J].

Cassier, Philippe A. ;

Italiano, Antoine ;

Gomez-Roca, Carlos ;

Le Tourneau, Christophe ;

Toulmonde, Maud ;

D'Angelo, Sandra P. ;

Weber, Kristy ;

Loirat, Delphine ;

Jacob, Wolfgang ;

Jegg, Anna-Maria ;

Michielin, Francesca ;

Christen, Randolph ;

Watson, Carl ;

Cannarile, Michael ;

Klaman, Irina ;

Abiraj, Keelara ;

Ries, Carola H. ;

Weisser, Martin ;

Ruttinger, Dominik ;

Blay, Jean-Yves ;

Delord, Jean-Pierre .

EUROPEAN JOURNAL OF CANCER, 2020, 141 :162-170

[18] The use of suramin, an antifibrotic agent, to improve muscle recovery after strain injury [J].

Chan, YS ;

Li, Y ;

Foster, W ;

Fu, FH ;

Huard, J .

AMERICAN JOURNAL OF SPORTS MEDICINE, 2005, 33 (01) :43-51

[19] Antifibrotic effects of suramin in injured skeletal muscle after laceration [J].

Chan, YS ;

Li, Y ;

Foster, W ;

Horaguchi, T ;

Somogyi, G ;

Fu, FH ;

Huard, J .

JOURNAL OF APPLIED PHYSIOLOGY, 2003, 95 (02) :771-780

[20] Satellite cells attract monocytes and use macrophages as a support to escape apoptosis and enhance muscle growth [J].

Chazaud, B ;

Sonnet, C ;

Lafuste, P ;

Bassez, G ;

Rimaniol, AC ;

Poron, F ;

Authier, FJ ;

Dreyfus, PA ;

Gherardi, RK .

JOURNAL OF CELL BIOLOGY, 2003, 163 (05) :1133-1143

← 1 2 3 4 5 6 7 8 9 10 →