Macrophages in the Context of Muscle Regeneration and Duchenne Muscular Dystrophy

被引：3
作者：
Hernandez-Torres, Francisco [1 ,2 ]
Matias-Valiente, Lidia [2 ,3 ]
Alzas-Gomez, Virginia [2 ,3 ]
Aranega, Amelia Eva [2 ,3 ]
机构：
[1] Univ Granada, Fac Med, Dept Biochem & Mol Biol & Immunol 3, Granada 18016, Spain
[2] Medina Fdn, Technol Pk Hlth Sci, Granada 18016, Spain
[3] Univ Jaen, Fac Expt Sci, Dept Expt Biol, Jaen 23071, Spain
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 19期
关键词：
macrophages; inflammation; skeletal muscle; Duchenne muscular dystrophy; GLYCOGEN-SYNTHASE KINASE-3-BETA; TISSUE-RESIDENT MACROPHAGES; TUMOR-NECROSIS-FACTOR; QUALITY-OF-LIFE; GROWTH-FACTOR-I; SKELETAL-MUSCLE; SATELLITE CELLS; TNF-ALPHA; FIBRO/ADIPOGENIC PROGENITORS; DENDRITIC CELLS;
D O I：
10.3390/ijms251910393
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Macrophages are essential to muscle regeneration, as they regulate inflammation, carry out phagocytosis, and facilitate tissue repair. These cells exhibit phenotypic switching from pro-inflammatory (M1) to anti-inflammatory (M2) states during muscle repair, influencing myoblast proliferation, differentiation, and myofiber formation. In Duchenne Muscular Dystrophy (DMD), asynchronous muscle injuries disrupt the normal temporal stages of regeneration, leading to fibrosis and failed regeneration. Altered macrophage activity is associated with DMD progression and physiopathology. Gaining insight into the intricate relationship between macrophages and muscle cells is crucial for creating effective therapies aimed at treating this muscle disorder. This review explores the dynamic functions of macrophages in muscle regeneration and their implications in DMD.
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页数：22
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共 170 条
[1]   Interplay of IKK/NF-κB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy [J].
Acharyya, Swarnali ;
Villalta, S. Armando ;
Bakkar, Nadine ;
Bupha-Intr, Tepmanas ;
Janssen, Paul M. L. ;
Carathers, Micheal ;
Li, Zhi-Wei ;
Beg, Amer A. ;
Ghosh, Sankar ;
Sahenk, Zarife ;
Weinstein, Michael ;
Gardner, Katherine L. ;
Rafael-Fortney, Jill A. ;
Karin, Michael ;
Tidball, James G. ;
Baldwin, Albert S. ;
Guttridge, Denis C. .
JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (04) :889-901
[2]   Beneficial synergistic interactions of TNF-α and IL-6 in C2 skeletal myoblasts -: Potential cross-talk with IGF system [J].
Al-Shanti, Nasser ;
Saini, Amarjit ;
Faulkner, Steve H. ;
Stewart, Claire E. .
GROWTH FACTORS, 2008, 26 (02) :61-73
[3]   Calcium and the damage pathways in muscular dystrophy [J].
Allen, David G. ;
Gervasio, Othon L. ;
Yeung, Ella W. ;
Whitehead, Nicholas P. .
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2010, 88 (02) :83-91
[4]   Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis [J].
Arnold, Ludovic ;
Henry, Adeline ;
Poron, Francoise ;
Baba-Amer, Yasmine ;
van Rooijen, Nico ;
Plonquet, Anne ;
Gherardi, Romain K. ;
Chazaud, Benedicte .
JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (05) :1057-1069
[5]   Role of Human Macrophage Polarization in Inflammation during Infectious Diseases [J].
Atri, Chiraz ;
Guerfali, Fatma Z. ;
Laouini, Dhafer .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (06)
[6]   Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior [J].
Auffray, Cedric ;
Fogg, Darin ;
Garfa, Meriem ;
Elain, Gaelle ;
Join-Lambert, Olivier ;
Kayal, Samer ;
Sarnacki, Sabine ;
Cumano, Ana ;
Lauvau, Gregoire ;
Geissmann, Frederic .
SCIENCE, 2007, 317 (5838) :666-670
[7]   Metabolic reprogramming of skeletal muscle by resident macrophages points to CSF1R inhibitors as muscular dystrophy therapeutics [J].
Babaeijandaghi, Farshad ;
Cheng, Ryan ;
Kajabadi, Nasim ;
Soliman, Hesham ;
Chang, Chih-Kai ;
Smandych, Josh ;
Tung, Lin Wei ;
Long, Reece ;
Ghassemi, Amirhossein ;
Rossi, Fabio M., V .
SCIENCE TRANSLATIONAL MEDICINE, 2022, 14 (651)
[8]   Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism [J].
Baht, Gurpreet S. ;
Bareja, Akshay ;
Lee, David E. ;
Rao, Rajesh R. ;
Huang, Rong ;
Huebner, Janet L. ;
Bartlett, David B. ;
Hart, Cory R. ;
Gibson, Jason R. ;
Lanza, Ian R. ;
Kraus, Virginia B. ;
Gregory, Simon G. ;
Spiegelman, Bruce M. ;
White, James P. .
NATURE METABOLISM, 2020, 2 (03) :278-+
[9]   Cellular dynamics in the muscle satellite cell niche [J].
Bentzinger, C. Florian ;
Wang, Yu Xin ;
Dumont, Nicolas A. ;
Rudnicki, Michael A. .
EMBO REPORTS, 2013, 14 (12) :1062-1072
[10]   TLR4 is a regulator of trained immunity in a murine model of Duchenne muscular dystrophy [J].
Bhattarai, Salyan ;
Li, Qian ;
Ding, Jun ;
Liang, Feng ;
Gusev, Ekaterina ;
Lapohos, Orsolya ;
Fonseca, Gregory J. ;
Kaufmann, Eva ;
Divangahi, Maziar ;
Petrof, Basil J. .
NATURE COMMUNICATIONS, 2022, 13 (01)
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