The telomere connection between aging and cancer: The burden of replication stress and dysfunction

被引：0
作者：
Boccardi, Virginia [1 ]
Marano, Luigi [2 ,3 ]
机构：
[1] Univ Perugia, Dept Med & Surg, Div Gerontol & Geriatr, Piazzale Gambuli 1, I-06132 Perugia, Italy
[2] Akad Med & Spolecznych Nauk Stosowanych, Acad Appl Med & Social Sci AMiSNS, Dept Med, 2 Lotnicza St, PL-82300 Elblag, Poland
[3] Nicolaus Copernicus Hlth Ctr, St Wojciech Hosp, Dept Gen Surg & Surg Oncol, Jana Pawla II 50, PL-80462 Gdansk, Poland
来源：
MECHANISMS OF AGEING AND DEVELOPMENT | 2025年 / 223卷
关键词：
Aging; Cancer; Telomeres; SENESCENCE; INSTABILITY; HALLMARKS; DISEASES; LENGTH; RISK; TRF1;
D O I：
10.1016/j.mad.2025.112026
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Aging is a complex process that affects individuals at the molecular, cellular, tissue, and systemic levels, arising from the cumulative effects of damage and reduced repair mechanisms. This process leads to the onset of age- related diseases, including cancer, which exhibits increased incidence with age. Telomeres, the protective caps at chromosome ends, play a crucial role in genome stability and are closely connected with aging and age-related disorders. Both excessively short and long telomere lengths may contribute to cancer development when their balance is disrupted. Fragile telomeres, characterized by abnormalities and replication stress, may provide novel insights into the connection between aging and cancer. The accumulation of fragile telomeres, possibly due to intense replicative stress, may represent a key factor. Given the dynamic nature of telomeres, large longitudinal studies are essential for understanding their role in aging and cancer susceptibility, which is crucial for developing effective strategies to promote healthy aging and mitigate cancer risk.
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页数：7
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