Alleviating D-Galactose-Induced Aging in Mice by Modulating Gut-Liver Axis Using Lactiplantibacillus plantarum TY-Y10

被引：0

作者：

Shi, Shaoqi ^{[1
]}

Li, Xiaoxia ^{[1
]}

Zhang, Feng ^{[2
]}

Jiang, Zhengqiang ^{[3
]}

Wang, Jing ^{[2
]}

Zhao, Liang ^{[4
]}

Chen, Juan ^{[1
]}

Shu, Xi ^{[2
]}

Fang, Bing ^{[5
]}

Liu, Ping ^{[1
]}

He, Jingjing ^{[4
]}

Ge, Shaoyang ^{[6
]}

Wang, Fuqing ^{[7
]}

Guo, Jie ^{[4
]}

Li, Yixuan ^{[4
]}

Luo, Jie ^{[8
]}

Wang, Ran ^{[1
]}

机构：

[1] China Agr Univ, Dept Nutr & Hlth, Key Lab Funct Dairy, Coconstructed Minist Educ & Beijing Govt, Beijing 100190, Peoples R China

[2] Chongqing Tianyou Dairy Co Ltd, Chongqing Key Lab Ind & Informatizat Probiot Ferme, Chongqing 401120, Peoples R China

[3] China Agr Univ, Coll Food Sci & Nutr Engn, Key Lab Food Bioengn, China Natl Light Ind, Beijing 100083, Peoples R China

[4] China Agr Univ, Res Ctr Probiot, Beijing 100083, Peoples R China

[5] Food Lab Zhongyuan, Luohe 462300, Peoples R China

[6] Hebei Engn Res Ctr Anim Prod, Sanhe 065200, Peoples R China

[7] Tibet Tianhong Sci & Technol Co Ltd, Lhasa 850000, Peoples R China

[8] Hunan Agr Univ, Coll Food Sci & Technol, Changsha 410114, Peoples R China

来源：

FOODS | 2024年 / 13卷 / 22期

关键词：

probiotic; aging; Nrf2 signaling pathway; gut microbiota; short-chain fatty acids; OXIDATIVE STRESS; CLOSTRIDIUM-CLOSTRIDIOFORME; CELLS; PROTECTS; HEALTH; NRF2;

D O I：

10.3390/foods13223618

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Oxidative stress is closely linked to aging. Probiotics, whether viable or heat-inactivated, have shown antioxidant properties; however, their effect and mechanism of action in reducing oxidative stress during aging remains underexplored. This study examined the effects of viable and heat-inactivated Lactiplantibacillus plantarum TY-Y10 (L. plantarum TY-Y10) on D-galactose (D-gal)-induced aging in mice, aiming to uncover potential anti-aging mechanisms. Mice were induced to age with D-gal injections, then treated with sodium ascorbate (positive control) or varying doses of L. plantarum TY-Y10 for eight weeks. After treatment, oxidative stress markers, gut microbiota, and liver health were analyzed. Results showed that L. plantarum TY-Y10 decreased malondialdehyde (MDA) and inflammatory markers while increasing antioxidant levels (glutathione, superoxide dismutase, catalase and glutathione peroxidase). Liver damage was reduced, and expression of Nrf2 and related antioxidant enzymes improved. Additionally, L. plantarum TY-Y10 enhanced the abundance of short-chain fatty acid-producing bacteria, boosting fecal short-chain fatty acid levels. In short, both viable and heat-inactivated L. plantarum TY-Y10 mitigated oxidative stress in aging mice by modulating gut microbiota and activating liver antioxidant pathways through the gut-liver axis.

引用

页数：21

共 72 条

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