SYNTHESIS AND CHARACTERIZATION OF BIOGENIC MAGNESIUM OXIDE NANOPARTICLES AS ANTIDIABETIC AGENTS

The-application of nanoparticles for accurate diagnosis and ample treatment to various human diseases. Despite the use of diverse polymers in nanoparticle synthesis, biosynthesis of these particles in viable, metal-tolerant microorganisms is preferred over all other prevalent procedures including chemical methods, because of its cost-effectiveness, and eco-friendliness. Diabetes is the most fifth growing trend prevalent diseases worldwide due to the lifestyle changes, physical inactivity, aging, nutrition and lack of diet nutrition. The disease spread is influenced by numerous hereditary facts, environmental causes, temporal and additional behaviour. The study purpose by using in-silico approach identify inhibitors binding with alpha glucosidase against DM. The alpha-glucosidase protein sequence from Saccharomycescerevisiae was retrieved using NCBI and utilizing software molecular docking and AdmetSAR were perormed. AdmetSAR utilized for the identification of properties of (ligand) MgONPs associate brain blood 0.9827% barrier and human intestinal 0.9848% absorption. MgONPs biodegradation 0.77% percentage was calculated with acute oral toxicity 0.589%. Total positive and negative charged residues Arg + Lys:73, Asp + Glu: 87 were also calculated. MgONPs exhibited super hydrogen bond formation interaction with polar amino acids, including ASP 37,SER 30, and LYS 39 residues of alpha glucosidase.64.28 aliphatic index with-0.670 (GRAVY) grand average hydropathicity. The 100 mu g /mL specimen cytotoxic concentration would be safe to ship. The alpha-glucosidase amino acids (ASP 46, VAL 325 and GLU 286) have a strong binding infinity with MgONPs. The amino acids of alpha-glucosidase (ASP 46, GLU 286 and VAL 325) have a strong binding interaction with MgONPs.