The Role of Genistein in Type 2 Diabetes and Beyond: Mechanisms and Therapeutic Potential

被引：0
作者：
Kciuk, Mateusz [1 ]
Kruczkowska, Weronika [2 ]
Wanke, Katarzyna [1 ]
Galeziewska, Julia [2 ]
Kolat, Damian [2 ,3 ]
Mujwar, Somdutt [4 ]
Kontek, Renata [1 ]
机构：
[1] Univ Lodz, Dept Mol Biotechnol & Genet, Banacha 12-16, PL-90237 Lodz, Poland
[2] Med Univ Lodz, Fac Med, Dept Funct Genom, Zeligowskiego 7-9, PL-90752 Lodz, Poland
[3] Med Univ Lodz, Fac Med, Dept Biomed & Expt Surg, Narutowicza 60, PL-90136 Lodz, Poland
[4] Chitkara Univ, Chitkara Coll Pharm, Rajpura 140401, Punjab, India
来源：
MOLECULES | 2025年 / 30卷 / 05期
关键词：
anti-oxidant; bioavailability; genistein; metabolic disease; natural product; type 2 diabetes mellitus; PURIFIED SOY ISOFLAVONES; PANCREATIC BETA-CELLS; SOYBEAN ISOFLAVONES; SYNTHETIC GENISTEIN; CLINICAL CHARACTERISTICS; POSTMENOPAUSAL WOMEN; BACKGROUND DIET; GUT MICROFLORA; IN-VITRO; BIOAVAILABILITY;
D O I：
10.3390/molecules30051068
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The global prevalence of type 2 diabetes mellitus (T2DM) necessitates the exploration of novel therapeutic approaches to mitigate its complex molecular pathogenesis. This review investigates the potential role of genistein, a prominent isoflavone derived from soybeans, in the management of T2DM. Recognized for its selective estrogen receptor modulator (SERM) activity, genistein exerts a multifaceted influence on key intracellular signaling pathways, which are crucial in regulating cell proliferation, apoptosis, and insulin signaling. Genistein's anti-inflammatory, anti-oxidant, and metabolic regulatory properties position it as a promising candidate for T2DM intervention. This review synthesizes current research spanning preclinical studies and clinical trials, emphasizing genistein's impact on insulin sensitivity, glucose metabolism, and inflammatory markers. Additionally, this review addresses genistein's bioavailability, safety, and potential influence on gut microbiota composition. By consolidating these findings, this review aims to provide a comprehensive understanding of genistein's therapeutic potential in T2DM management, offering valuable insights for future research and clinical practice.
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页数：40
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