Modified time-to-positivity as a crucial determinant of short-term mortality among adults with community-onset monomicrobial bloodstream infections

被引：0

作者：

Tsai, Pei-Fang ^{[1
]}

Hong, Ming-Yuan ^{[2
,3
]}

Lee, Chung-Hsun ^{[2
,3
]}

Chi, Chih-Hsien ^{[2
,3
]}

Lee, Ching-Chi ^{[3
,4
]}

Ko, Wen-Chien ^{[3
,4
]}

机构：

[1] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Pathol, Tainan, Taiwan

[2] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Emergency Med, Tainan, Taiwan

[3] Natl Cheng Kung Univ, Med Coll, Dept Med, Tainan, Taiwan

[4] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Internal Med, Tainan, Taiwan

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2025年 / 111卷 / 04期

关键词：

Bloodstream infection; Time-to-positivity; Transportation time; Source control; Antimicrobial therapy; Mortality; CULTURES; EPIDEMIOLOGY; DIAGNOSIS;

D O I：

10.1016/j.diagmicrobio.2025.116738

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The potential performance of time-to-positivity (TTP) in predicting the prognosis of individuals experiencing Bloodstream infections (BSIs) has achieved little consensus. The retrospective cohort of 1015 treatment-naive adults with community-onset monomicrobial BSIs aimed to assess the performance of TTP and modified TTP (mTTP, TTP plus transportation time) in predicting 30-day mortality after adjusting for prognostic confounders, particularly the time-to-appropriate antibiotic (TtAa). Through Spearman's correlation, a significant linear-by- linear association (rho =-0.943, P = 0.005) was exhibited between mTTP and 30-day mortality rates, but no significant association (rho =-0.423, P = 0.26) was disclosed between TTP and 30-day mortality rates in the overall patient population. In the logistic regression model, each additional hour of mTTP or TTP was associated with an average decrease of 5 % (adjusted odds ratio [AOR], 0.95; P = 0.001) or 3 % (AOR, 0.97; P = 0.03) in the 30-day mortality rates, respectively, after adjusting for independent predictors of 30-day mortality. In conclusion, for adults with community-onset monomicrobial BSIs, mTTP revealed a favorable performance over TTP alone in predicting short-term mortality.

引用

页数：9

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