The Evolution of Antimicrobial Resistance in Acinetobacter baumannii and New Strategies to Fight It

被引：5

作者：

Scoffone, Viola Camilla ^{[1
]}

Trespidi, Gabriele ^{[1
]}

Barbieri, Giulia ^{[1
]}

Arshad, Arooba ^{[1
]}

Israyilova, Aygun ^{[2
,3
]}

Buroni, Silvia ^{[1
]}

机构：

[1] Univ Pavia, Dept Biol & Biotechnol, I-27100 Pavia, Italy

[2] Baku State Univ, Ctr Excellence, Lab Microbiol, AZ-1148 Baku, Azerbaijan

[3] Baku State Univ, Dept Biomed Mat ICESCO, AZ-1148 Baku, Azerbaijan

来源：

ANTIBIOTICS-BASEL | 2025年 / 14卷 / 01期

关键词：

Acinetobacter baumannii; drug resistance; new therapy; AMINOGLYCOSIDE RESISTANCE; COLISTIN-RESISTANCE; INSERTION-SEQUENCE; AMPC GENE; PLASMID; CLONE; MECHANISMS; LIPOPOLYSACCHARIDE; BLA(OXA-23); EMERGENCE;

D O I：

10.3390/antibiotics14010085

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Acinetobacter baumannii is considered one of the prioritized ESKAPE microorganisms for the research and development of novel treatments by the World Health Organization, especially because of its remarkable persistence and drug resistance. In this review, we describe how this can be acquired by the enzymatic degradation of antibiotics, target site modification, altered membrane permeability, multidrug efflux pumps, and their ability to form biofilms. Also, the evolution of drug resistance in A. baumannii, which is mainly driven by mobile genetic elements, is reported, with particular reference to plasmid-associated resistance, resistance islands, and insertion sequences. Finally, an overview of existing, new, and alternative therapies is provided.

引用

页数：19

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