The Effect of the Acid-Base Imbalance on the Shape and Structure of Red Blood Cells

被引：0
作者：
Kandrashina, Snezhanna [1 ]
Sherstyukova, Ekaterina [1 ]
Shvedov, Mikhail [1 ]
Inozemtsev, Vladimir [1 ]
Timoshenko, Roman [2 ]
Erofeev, Alexander [2 ]
Dokukin, Maxim [3 ]
Sergunova, Viktoria [1 ]
机构：
[1] VA Negovsky Res Inst Gen Reanimatol, Fed Res & Clin Ctr Intens Care Med & Rehabilitol, Moscow 107031, Russia
[2] Natl Univ Sci & Technol MISIS, Res Lab Biophys, Moscow 119049, Russia
[3] MEPhI, Sarov Phys & Technol Inst, Sarov 607186, Russia
来源：
CELLS | 2024年 / 13卷 / 21期
关键词：
red blood cell; pH; ROS; AFM; SICM; nanostructure; cytoskeleton; elastic modulus; ERYTHROCYTE-GHOSTS; PH; MORPHOLOGY; ASPHYXIA; LACTATE;
D O I：
10.3390/cells13211813
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Red blood cells respond to fluctuations in blood plasma pH by changing the rate of biochemical and physical processes that affect the specific functions of individual cells. This study aimed to analyze the effect of pH changes on red blood cell morphology and structure. The findings revealed that an increase or decrease in pH above or below the physiological level of pH 7.4 results in the transformation of discocytes into echinocytes and causes significant alterations in the membrane, including its roughness, cytoskeleton structure, and the cell's elastic modulus. Furthermore, the study shown a strong connection between critical acidosis and alkalosis with increased intracellular reactive oxygen species production.
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页数：14
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