Active role of the immune system in metabolic dysfunction-associated steatotic liver disease

被引：5

作者：

Mori, Taizo ^{[1
]}

Yoshio, Sachiyo ^{[1
]}

Kakazu, Eiji ^{[1
]}

Kanto, Tatsuya ^{[1
]}

机构：

[1] Natl Ctr Global Hlth & Med, Res Ctr Hepatitis & Immunol, Dept Liver Dis, Chiba, Japan

来源：

GASTROENTEROLOGY REPORT | 2024年 / 12卷

关键词：

MASLD; MASH; innate immunity; liver fibrosis; inflammatory cytokine; KILLER T-CELLS; NEUTROPHIL EXTRACELLULAR TRAPS; NONALCOHOLIC STEATOHEPATITIS; DENDRITIC CELLS; NK CELLS; TRANSCRIPTIONAL REGULATION; HEPATIC STEATOSIS; OBETICHOLIC ACID; CONTROLLED-TRIAL; INFLAMMATION;

D O I：

10.1093/gastro/goae089

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Non-alcoholic fatty liver disease, recently renamed metabolic dysfunction-associated steatotic liver disease (MASLD), is a complex multifactorial disease that progresses from steatohepatitis (MASH) to liver cirrhosis and liver cancer. Recent research has revealed that crosstalk between innate immune cells and hepatic parenchymal and non-parenchymal cells is involved in the pathogenesis of liver disease in MASLD/MASH. Of particular importance, novel inflammatory mechanisms, including macrophage diversity, neutrophil NETosis, B-cell biology, auto-reactive T cells, unconventional T cells, and dendritic cell-T cell interactions, are considered key drivers for disease progression. These mechanisms and factors are potential targets for the therapeutic intervention of MASLD/MASH. In this review, we focus on recent discoveries related to liver inflammation and discuss the role of innate immune cell subsets in MASLD/MASH.

引用

页数：11

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