Increased Bone Morphogenetic Protein-Responsive Transcription Factors in Distinct Endothelial and Mesenchymal Cells in Pulmonary Artery Hypertension

被引：0

作者：

Andruska, Adam Michael ^{[1
,2
,3
]}

Valadez, Rodrigo Cantu ^{[6
]}

Ichimura, Kenzo ^{[1
,2
,3
]}

Chu, Pauline ^{[4
]}

Zhang, Tianyi ^{[1
]}

Schimmel, Katharina ^{[1
,2
,3
]}

Wang, Lingli ^{[5
]}

Cao, Aiqin ^{[5
]}

Aldred, Micheala A. ^{[7
]}

Spiekerkoetter, Edda ^{[1
,2
,3
]}

机构：

[1] Stanford Univ, Dept Med, Div Pulm Allergy & Crit Care Med, 1701 Page Mill Rd, Room 141, Palo Alto, CA 94304 USA

[2] Stanford Univ, Vera Moulton Wall Ctr Pulm Vasc Dis, Stanford, CA USA

[3] Stanford Univ, Cardiovasc Inst, Stanford, CA USA

[4] Stanford Univ, Dept Pathol, Stanford, CA USA

[5] Stanford Univ, Dept Pediat, Div Cardiol, Stanford, CA USA

[6] Univ Calif Berkeley, Dept Phys, Berkeley, CA USA

[7] Indiana Univ Sch Med, Dept Med, Indianapolis, IN USA

来源：

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | 2025年 / 211卷 / 01期

关键词：

RECEPTOR; EXPRESSION; MUTATIONS; BMPR2;

D O I：

10.1164/rccm.202405-1039LE

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

引用

页码：127 / 130

页数：4

共 14 条

[1]

Andruska AM, 2023, AM J RESP CRIT CARE, V207

[2] Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor [J].

Atkinson, C ;

Stewart, S ;

Upton, PD ;

Machado, R ;

Thomson, JR ;

Trembath, RC ;

Morrell, NW .

CIRCULATION, 2002, 105 (14) :1672-1678

[3] Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene [J].

Deng, ZM ;

Morse, JH ;

Slager, SL ;

Cuervo, N ;

Moore, KJ ;

Venetos, G ;

Kalachikov, S ;

Cayanis, E ;

Fischer, SG ;

Barst, RJ ;

Hodge, SE ;

Knowles, JA .

AMERICAN JOURNAL OF HUMAN GENETICS, 2000, 67 (03) :737-744

[4] Sotatercept for the Treatment of Pulmonary Arterial Hypertension [J].

Humbert, Marc ;

McLaughlin, Vallerie ;

Gibbs, J. Simon R. ;

Gomberg-Maitland, Mardi ;

Hoeper, Marius M. ;

Preston, Ioana R. ;

Souza, Rogerio ;

Waxman, Aaron ;

Escribano Subias, Pilar ;

Feldman, Jeremy ;

Meyer, Gisela ;

Montani, David ;

Olsson, Karen M. ;

Manimaran, Solaiappan ;

Barnes, Jennifer ;

Linde, Peter G. ;

de Oliveira Pena, Janethe ;

Badesch, David B. .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (13) :1204-1215

[5] Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter [J].

Korchynskyi, O ;

ten Dijke, P .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (07) :4883-4891

[6] Heterozygous germline mutations in BMPR2, encoding a TGF-β receptor, cause familial primary pulmonary hypertension [J].

Lane, KB ;

Machado, RD ;

Pauciulo, MW ;

Thomson, JR ;

Phillips, JA ;

Loyd, JE ;

Nichols, WC ;

Trembath, RC .

NATURE GENETICS, 2000, 26 (01) :81-84

[7] BMP type II receptor as a therapeutic target in pulmonary arterial hypertension [J].

Orriols, Mar ;

Gomez-Puerto, Maria Catalina ;

ten Dijke, Peter .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2017, 74 (16) :2979-2995

[8] FK506 activates BMPR2 rescues endothelial dysfunction, and reverses pulmonary hypertension [J].

Spiekerkoetter, Edda ;

Tian, Xuefei ;

Cai, Jie ;

Hopper, Rachel K. ;

Sudheendra, Deepti ;

Li, Caiyun G. ;

El-Bizri, Nesrine ;

Sawada, Hirofumi ;

Haghighat, Roxanna ;

Chan, Roshelle ;

Haghighat, Leila ;

Perez, Vinicio de Jesus ;

Wang, Lingli ;

Reddy, Sushma ;

Zhao, Mingming ;

Bernstein, Daniel ;

Solow-Cordero, David E. ;

Beachy, Philip A. ;

Wandless, Thomas J. ;

ten Dijke, Peter ;

Rabinovitch, Marlene .

JOURNAL OF CLINICAL INVESTIGATION, 2013, 123 (08) :3600-3613

[9] A molecular cell atlas of the human lung from single-cell RNA sequencing [J].

Travaglini, Kyle J. ;

Nabhan, Ahmad N. ;

Penland, Lolita ;

Sinha, Rahul ;

Gillich, Astrid ;

Sit, Rene V. ;

Chang, Stephen ;

Conley, Stephanie D. ;

Mori, Yasuo ;

Seita, Jun ;

Berry, Gerald J. ;

Shrager, Joseph B. ;

Metzger, Ross J. ;

Kuo, Christin S. ;

Neff, Norma ;

Weissman, Irving L. ;

Quake, Stephen R. ;

Krasnow, Mark A. .

NATURE, 2020, 587 (7835) :619-625

[10] Digital Spatial Profiling Identifies Distinct Molecular Signatures of Vascular Lesions in Pulmonary Arterial Hypertension [J].

Tuder, Rubin M. ;

Gandjeva, Aneta ;

Williams, Sarah ;

Kumar, Sushil ;

Kheyfets, Vitaly O. ;

Hatton-Jones, Kyle Matthew ;

Starr, Jacqueline R. ;

Yun, Jeong ;

Hong, Jason ;

West, Nicholas P. ;

Stenmark, Kurt R. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2024, 210 (03) :329-342

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