Effect of Prior Influenza A(H1N1)pdm09 Virus Infection on Pathogenesis and Transmission of Influenza A(H5N1) Clade 2.3.4.4b Virus in Ferret Model

被引：2

作者：

Sun, Xiangjie ^{[1
]}

Belser, Jessica A. ^{[1
]}

Li, Zhu-Nan ^{[1
]}

Brock, Nicole ^{[1
]}

Pulit-Penaloza, Joanna A. ^{[1
]}

Kieran, Troy J. ^{[1
]}

Pappas, Claudia ^{[1
]}

Zeng, Hui ^{[1
]}

Chang, Jessie C. ^{[1
]}

Carney, Paul J. ^{[1
]}

Bradley-Ferrell, Brandon L. ^{[1
]}

Stevens, James ^{[1
]}

Tumpey, Terrence M. ^{[1
]}

Levine, Min Z. ^{[1
]}

Maines, Taronna R. ^{[1
]}

机构：

[1] CDCP, 1600 Clifton Rd NE,Mailstop H17-5, Atlanta, GA 30329 USA

来源：

EMERGING INFECTIOUS DISEASES | 2025年 / 31卷 / 03期

关键词：

H5N1; PROTECTION; ANTIBODY; EXPOSURE;

D O I：

10.3201/eid3103.241489

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Reports of human infections with influenza A(H5N1) clade 2.3.4.4b viruses associated with outbreaks in dairy cows in the United States underscore the need to assess the potential cross-protection conferred by existing influenza immunity. We serologically evaluated ferrets previously infected with an influenza A(H1N1)pdm09 virus for cross-reactive antibodies and then challenged 3 months later with either highly pathogenic H5N1 clade 2.3.4.4b or low pathogenicity H7N9 virus. Our results showed that prior influenza A(H1N1)pdm09 virus infection more effectively reduced the replication and transmission of the H5N1 virus than did the H7N9 virus, a finding supported by the presence of group 1 hemagglutinin stalk and N1 neuraminidase antibodies in preimmune ferrets. Our findings suggest that prior influenza A(H1N1)pdm09 virus infection may confer some level of protection against influenza A(H5N1) clade 2.3.4.4.b virus.

引用

页码：458 / 466

页数：9

共 34 条

[1] Pathogenesis and transmission of avian influenza A (H7N9) virus in ferrets and mice [J].

Belser, Jessica A. ;

Gustin, Kortney M. ;

Pearce, Melissa B. ;

Maines, Taronna R. ;

Zeng, Hui ;

Pappas, Claudia ;

Sun, Xiangjie ;

Carney, Paul J. ;

Villanueva, Julie M. ;

Stevens, James ;

Katz, Jacqueline M. ;

Tumpey, Terrence M. .

NATURE, 2013, 501 (7468) :556-+

[2]

Bevins SN, 2022, EMERG INFECT DIS, V28, P1006, DOI [10.3201/eid2805.220218, 10.3201/eid2805.220318]

[3] H1N1, but Not H3N2, Influenza A Virus Infection Protects Ferrets from H5N1 Encephalitis [J].

Bissel, Stephanie J. ;

Wang, Guoji ;

Carter, Donald M. ;

Crevar, Corey J. ;

Ross, Ted M. ;

Wiley, Clayton A. .

JOURNAL OF VIROLOGY, 2014, 88 (06) :3077-3091

[4] Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b Virus Infection in Domestic Dairy Cattle and Cats, United States, 2024 [J].

Burrough, Eric R. ;

Magstadt, Drew R. ;

Petersen, Barbara ;

Timmermans, Simon J. ;

Gauger, Phillip C. ;

Zhang, Jianqiang ;

Siepker, Chris ;

Mainenti, Marta ;

Li, Ganwu ;

Thompson, Alexis C. ;

Gorden, Patrick J. ;

Plummer, Paul J. ;

Main, Rodger .

EMERGING INFECTIOUS DISEASES, 2024, 30 (07) :1335-1343

[5] Transatlantic spread of highly pathogenic avian influenza H5N1 by wild birds from Europe to North America in 2021 [J].

Caliendo, V ;

Lewis, N. S. ;

Pohlmann, A. ;

Baillie, S. R. ;

Banyard, A. C. ;

Beer, M. ;

Brown, I. H. ;

Fouchier, R. A. M. ;

Hansen, R. D. E. ;

Lameris, T. K. ;

Lang, A. S. ;

Laurendeau, S. ;

Lung, O. ;

Robertson, G. ;

van der Jeugd, H. ;

Alkie, T. N. ;

Thorup, K. ;

van Toor, M. L. ;

Waldenstrom, J. ;

Yason, C. ;

Kuiken, T. ;

Berhane, Y. .

SCIENTIFIC REPORTS, 2022, 12 (01)

[6]

Centers for Disease Control and Prevention, CDC's influenza risk assessment tool (IRAT)

[7]

Centers for Disease Control and Prevention, CDC reports fourth human case of H5 bird flu tied to dairy cow outbreak cited 2024 Aug 301

[8] Serological evidence of human infections with highly pathogenic avian influenza A(H5N1) virus: a systematic review and meta-analysis [J].

Chen, Xinhua ;

Wang, Wei ;

Wang, Yan ;

Lai, Shengjie ;

Yang, Juan ;

Cowling, Benjamin J. ;

Horby, Peter W. ;

Uyeki, Timothy M. ;

Yu, Hongjie .

BMC MEDICINE, 2020, 18 (01)

[9] Avian Influenza A(H5N1) Neuraminidase Inhibition Antibodies in Healthy Adults after Exposure to Influenza A(H1N1)pdm09 [J].

Daulagala, Pavithra ;

Cheng, Samuel M. S. ;

Chin, Alex ;

Luk, Leo L. H. ;

Leung, Kathy ;

Wu, Joseph T. ;

Poon, Leo L. M. ;

Peiris, Malik ;

Yen, Hui-Ling .

EMERGING INFECTIOUS DISEASES, 2024, 30 (01) :168-171

[10] Pathogenicity and transmissibility of bovine H5N1 influenza virus [J].

Eisfeld, Amie J. ;

Biswas, Asim ;

Guan, Lizheng ;

Gu, Chunyang ;

Maemura, Tadashi ;

Trifkovic, Sanja ;

Wang, Tong ;

Babujee, Lavanya ;

Dahn, Randall ;

Halfmann, Peter J. ;

Barnhardt, Tera ;

Neumann, Gabriele ;

Suzuki, Yasuo ;

Thompson, Alexis ;

Swinford, Amy K. ;

Dimitrov, Kiril M. ;

Poulsen, Keith ;

Kawaoka, Yoshihiro .

NATURE, 2024, 633 (8029) :426-432

← 1 2 3 4 →