Deficient SARS-CoV-2 hybrid immunity during inflammatory bowel disease

被引：0

作者：

Alirezaylavasani, Amin ^{[1
,2
,3
]}

Egner, Ingrid Marie ^{[1
,2
,3
]}

Dahl, Borresdatter ^{[4
]}

Chopra, Adity ^{[1
,3
,5
]}

Kasahara, Taissa de Matos ^{[1
]}

Goll, Guro Lovik ^{[6
,7
]}

Jahnsen, Jorgen ^{[8
,9
]}

Grodeland, Gunnveig ^{[1
,9
]}

Vaage, John Torgils ^{[1
,9
]}

Lund-Johansen, Fridtjof ^{[1
,3
,5
]}

Holter, Jan Cato ^{[9
,10
]}

Halvorsen, Bente ^{[4
,9
]}

Jorgensen, Kristin Kaasen ^{[8
]}

Munthe, Ludvig A. ^{[1
,2
,3
]}

Kared, Hassen ^{[1
,2
,3
]}

机构：

[1] Oslo Univ Hosp, Dept Immunol, Oslo, Norway

[2] Univ Oslo, Inst Clin Med, KG Jebsen Ctr B Cell Malignancies, Oslo, Norway

[3] Univ Oslo, Precis Immunotherapy Alliance, Oslo, Norway

[4] Oslo Univ Hosp, Res Inst Internal Med, Oslo, Norway

[5] Univ Oslo, ImmunoLingo Convergence Ctr, Oslo, Norway

[6] Diakonhjemmet Hosp, Div Rheumatol & Res, Oslo, Norway

[7] Univ Oslo, Fac Med, Inst Hlth & Soc, Oslo, Norway

[8] Akershus Univ Hosp, Dept Gastroenterol, Lorenskog, Norway

[9] Univ Oslo, Inst Clin Med, Oslo, Norway

[10] Oslo Univ Hosp, Dept Microbiol, Oslo, Norway

来源：

CLINICAL IMMUNOLOGY | 2025年 / 271卷

关键词：

IBD; Hybrid immunity; Inflammation; Antibody waning; Activation; TNF inhibitors; COVID-19; VACCINATION; CALPROTECTIN; THERAPY; MARKER; 3RD;

D O I：

10.1016/j.clim.2024.110404

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Patients with Inflammatory Bowel Disease (IBD) undergoing immunosuppressive therapies face heightened susceptibility to severe COVID-19. An in-depth understanding of systemic inflammation and cellular immune responses after SARS-CoV-2 vaccination and breakthrough infections (BTI) is required for optimizing vaccine strategies in this population. While the prevalence of high serological responders post- third COVID-19 vaccine dose was lower, and the antibody waning was higher in IBD patients than in healthy donors (HD), IBD patients showed an increase in anti-RBD Wild Type IgG levels and cross-reactive Spike -specific memory B cells following BTI. However, there was no significant enhancement in cellular immune responses against anti-SARS-CoV-2 post-BTI, with responses instead characterized by activation of SARS-CoV-2 specific and also bystander CD8 T cells. These results suggest a complex interaction between chronic inflammation in IBD and the generation of new immune responses, highlighting the need for tailored vaccine regimens and anti-inflammatory therapies to boost cellular immunity against SARS-CoV-2.

引用

页数：13