Epidemiology and pathogenesis of the link between rheumatoid arthritis and periodontitis

被引：0
作者：
Fang, Huiya [1 ]
Lin, Jin [1 ]
Qiu, Yiwu [2 ]
Cheng, Zijian [3 ]
Chen, Weiqian [1 ]
机构：
[1] Zhejiang Univ, Affiliated Hosp 1, Div Rheumatol, Sch Med, Hangzhou 310003, Peoples R China
[2] Zhejiang Chinese Med Univ, Sch Basic Med Sci, Hangzhou 310053, Peoples R China
[3] Zhejiang Univ, Stomatol Hosp, Sch Med, Zhejiang Prov Clin Res Ctr Oral Dis,Key Lab Oral B, Hangzhou 310000, Peoples R China
来源：
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B | 2025年
基金：
中国国家自然科学基金;
关键词：
Rheumatoid arthritis; Periodontitis; Pathogenesis; Citrullination; Anti-citrullinated protein antibody (ACPA); PORPHYROMONAS-GINGIVALIS; PEPTIDYLARGININE DEIMINASE-4; ANTIMICROBIAL PEPTIDES; CCP ANTIBODIES; SHARED EPITOPE; SMOKING; RISK; DISEASES; CLASSIFICATION; CITRULLINATION;
D O I：
10.1631/jzus.B2300519
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Rheumatoid arthritis (RA), an autoimmune disease characterized by chronic inflammation of synovial tissue, is divided into two subtypes-anti-citrullinated protein antibody (ACPA)-positive and ACPA-negative RA. While the pathogenic mechanisms of ACPA-positive RA are well-understood, the etiology of ACPA-negative RA remains largely unknown. The association between RA and periodontitis (PD) has been observed since the early 1900s, with the two diseases sharing common genetic and environmental risk factors that lead to the progressive destruction of bone and connective tissue. However, the associations between PD and the two subtypes of RA differ. This comprehensive review aims to provide an updated understanding of the epidemiological association between RA and PD, explore potential pathogenic mechanisms linking the two diseases, and highlight the key distinctions between the subtypes of RA and their respective associations with PD. We also discuss the possibility of early intervention or the treatment of the two diseases. Ultimately, this review aims to provide valuable insights for future research in this field.
引用
收藏
页码：448 / 460
页数：13
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