The role of lipase maturation factor 1 in hypertriglyceridaemia and atherosclerosis: An update

被引：1

作者：

Dabravolski, Siarhei A. ^{[1
]}

Churov, Alexey, V ^{[2
]}

Sukhorukov, Vasily N. ^{[2
]}

Kovyanova, Tatiana, I ^{[2
,3
]}

Beloyartsev, Dmitry F. ^{[2
]}

Lyapina, Irina N. ^{[2
,4
]}

Orekhov, Alexander N. ^{[2
]}

机构：

[1] Braude Acad Coll Engn, Dept Biotechnol Engn, Snunit 51,POB 78, IL-2161002 Karmiel, Israel

[2] Inst Gen Pathol & Pathophysiol, Moscow, Russia

[3] Inst Atherosclerosis Res, Moscow, Russia

[4] Res Inst Complex Issues Cardiovasc Dis, Kemerovo, Russia

来源：

SAGE OPEN MEDICINE | 2024年 / 12卷

基金：

俄罗斯科学基金会;

关键词：

lipase maturation factor 1; lipoprotein lipase; atherosclerosis; circular RNA; hypertriglyceridaemia; TRIGLYCERIDE-RICH LIPOPROTEINS; ENDOPLASMIC-RETICULUM STRESS; MUSCLE-CELL PROLIFERATION; CARDIOVASCULAR-DISEASE; REMNANT CHOLESTEROL; LDL CHOLESTEROL; VLDL RECEPTOR; LMF1; PROTEIN; RISK;

D O I：

10.1177/20503121241289828

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Lipase maturation factor 1 is an endoplasmic reticulum-resident transmembrane protein, which acts as a critical chaperone necessary for the folding, dimerisation, and secretion of lipases. In this review, we summarise data about the recently revealed role of lipase maturation factor 1 in endoplasmic reticulum redox homeostasis, its novel interaction partners among oxidoreductases and lectin chaperones, and the identification of fibronectin and the low-density lipoprotein receptor as novel non-lipase client proteins of lipase maturation factor 1. Additionally, the role of lipase maturation factor 1-derived circular RNA in atherosclerosis progression via the miR-125a-3p/vascular endothelial growth factor A\Fibroblast Growth Factor 1 axis is discussed. Finally, we focus on the causative role of lipase maturation factor 1 variants in the development of hypertriglyceridaemia - a type of dyslipidaemia that significantly contributes to the development of atherosclerosis and other cardiovascular diseases via different mechanisms.

引用

页数：12

共 117 条

[1]

Aberra T., 2020, J Clin Lipidol, V447

[2] The Genetic Spectrum of Familial Hypertriglyceridemia in Oman [J].

Al-Waili, Khalid ;

Al-Rasadi, Khalid ;

Al-Bulushi, Muna ;

Habais, Mohammed ;

Al-Mujaini, Abdullah ;

Al-Yaarubi, Saif ;

Rimbert, Antoine ;

Zadjali, Razan ;

Khaniabadi, Pegah Moradi ;

Al-Barwani, Hamida ;

Hasary, Sana ;

Al-Dahmani, Zayana M. ;

Al-Badi, Hala ;

Al-Maawali, Almundher ;

Zadjali, Fahad .

FRONTIERS IN GENETICS, 2022, 13

[3] Genetic Determinants of Lipids and Cardiovascular Disease Outcomes A Wide-Angled Mendelian Randomization Investigation [J].

Allara, Elias ;

Morani, Gabriele ;

Carter, Paul ;

Gkatzionis, Apostolos ;

Zuber, Verena ;

Foley, Christopher N. ;

Rees, Jessica M. B. ;

Mason, Amy M. ;

Bell, Steven ;

Gill, Dipender ;

Lindstrom, Sara ;

Butterworth, Adam S. ;

Di Angelantonio, Emanuele ;

Peters, James ;

Burgess, Stephen .

CIRCULATION-GENOMIC AND PRECISION MEDICINE, 2019, 12 (12) :543-551

[4] Circular RNA in cardiovascular disease [J].

Altesha, M-Ashraf ;

Ni, Tiffany ;

Khan, Afaan ;

Liu, Kexiang ;

Zheng, Xiufen .

JOURNAL OF CELLULAR PHYSIOLOGY, 2019, 234 (05) :5588-5600

[5] Triglyceride Levels and Residual Risk of Atherosclerotic Cardiovascular Disease Events and Death in Adults Receiving Statin Therapy for Primary or Secondary Prevention: Insights From the KP REACH Study [J].

Ambrosy, Andrew P. ;

Yang, Jingrong ;

Sung, Sue Hee ;

Allen, Amanda R. ;

Fitzpatrick, Jesse K. ;

Rana, Jamal S. ;

Wagner, Jeffrey ;

Philip, Sephy ;

Abrahamson, David ;

Granowitz, Craig ;

Go, Alan S. .

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2021, 10 (20)

[6] Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration [J].

Angelakopoulou, Aspasia ;

Shah, Tina ;

Sofat, Reecha ;

Shah, Sonia ;

Berry, Diane J. ;

Cooper, Jackie ;

Palmen, Jutta ;

Tzoulaki, Ioanna ;

Wong, Andrew ;

Jefferis, Barbara J. ;

Maniatis, Nikolas ;

Drenos, Fotios ;

Gigante, Bruna ;

Hardy, Rebecca ;

Laxton, Ross C. ;

Leander, Karin ;

Motterle, Anna ;

Simpson, Iain A. ;

Smeeth, Liam ;

Thomson, Andy ;

Verzilli, Claudio ;

Kuh, Diana ;

Ireland, Helen ;

Deanfield, John ;

Caulfield, Mark ;

Wallace, Chris ;

Samani, Nilesh ;

Munroe, Patricia B. ;

Lathrop, Mark ;

Fowkes, F. Gerry R. ;

Marmot, Michael ;

Whincup, Peter H. ;

Whittaker, John C. ;

de Faire, Ulf ;

Kivimaki, Mika ;

Kumari, Meena ;

Hypponen, Elina ;

Power, Chris ;

Humphries, Steve E. ;

Talmud, Philippa J. ;

Price, Jackie ;

Morris, Richard W. ;

Ye, Shu ;

Casas, Juan P. ;

Hingorani, Aroon D. .

EUROPEAN HEART JOURNAL, 2012, 33 (03) :393-407

[7] Association of Hypertriglyceridemia with All-Cause Mortality and Atherosclerotic Cardiovascular Events in a Low-Risk Italian Population: The TG-REAL Retrospective Cohort Analysis [J].

Arca, Marcello ;

Veronesi, Chiara ;

D'Erasmo, Laura ;

Borghi, Claudio ;

Colivicchi, Furio ;

De Ferrari, Gaetano Maria ;

Desideri, Giovambattista ;

Pontremoli, Roberto ;

Temporelli, Pier Luigi ;

Perrone, Valentina ;

Degli Esposti, Luca .

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2020, 9 (19)

[8] Purification, cellular levels, and functional domains of lipase maturation factor 1 [J].

Babilonia-Rosa, Melissa A. ;

Neher, Saskia B. .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2014, 450 (01) :423-428

[9] The Elusive Origin of Atherosclerotic Plaque Calcification [J].

Canet-Soulas, Emmanuelle ;

Bessueille, Laurence ;

Mechtouff, Laura ;

Magne, David .

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 9

[10] Research progress of signaling pathways of the natural substances intervene dyslipidemia (Review) [J].

Cao, Ningning ;

Li, Xiaoxuan ;

Zhang, Wanjing ;

Wang, Qingguo ;

Liang, Yujuan ;

Zhou, Fujun ;

Xiao, Xuefeng .

EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2022, 24 (02)

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