Latest Developments in Targeted Biological Therapies in the Management of Chordoma and Chondrosarcoma

被引：0

作者：

Biczo, Adam ^{[1
,2
]}

Sahgal, Arjun ^{[3
]}

Verlaan, Jorrit-Jan ^{[4
]}

Shreyaskumar, Patel ^{[5
]}

Szoverfi, Zsolt ^{[1
,2
]}

Schultheiss, Markus ^{[6
]}

Rhines, Laurence ^{[7
]}

Reynolds, Jeremy ^{[8
]}

Laufer, Ilya ^{[9
]}

Gasbarrini, Alessandro ^{[10
]}

Dea, Nicolas ^{[11
,12
]}

Gokaslan, Ziya ^{[13
]}

Fisher, Charles ^{[14
,15
]}

Bettegowda, Chetan ^{[16
]}

Boriani, Stefano ^{[10
]}

Hornicek, Francis ^{[17
,18
]}

Goodwin, Rory ^{[19
]}

Lazary, Aron ^{[1
,2
]}

机构：

[1] Natl Ctr Spinal Disorders, Kirlyhago U 1-3, H-1126 Budapest, Hungary

[2] Buda Hlth Ctr, Kirlyhago U 1-3, H-1126 Budapest, Hungary

[3] Univ Toronto, Odette Canc Ctr, Sunnybrook Hlth Sci Ctr, Dept Radiat Oncol, Toronto, ON, Canada

[4] Univ Utrecht, Univ Med Ctr Utrecht, Dept Orthopaed Surg, Utrecht, Netherlands

[5] Univ Texas MD Anderson Canc Ctr, Dept Sarcoma Med Oncol, Houston, TX USA

[6] Univ Ulm, Dept Trauma Surg, Ulm, Germany

[7] Univ Texas MD Anderson Canc Ctr, Houston, TX USA

[8] Oxford Univ Hosp NHS Fdn Trust, Oxford Univ Hosp NHS Trust, Oxford, England

[9] NYU Langone Langone Hlth, Dept Neurosurg, Div Spinal Neurosurg, New York, NY USA

[10] IRCCS Ist Ortoped Rizzoli, Ortopedia & Traumatol Rizzoli Argenta, Bologna, Italy

[11] Vancouver Gen Hosp, Div Spine Surg, Vancouver, BC, Canada

[12] Univ British Columbia, Vancouver, BC, Canada

[13] Brown Univ, Warren Alpert Med Sch, Providence, RI USA

[14] Univ British Columbia, Dept Orthopaed, Div Spine, Vancouver, BC, Canada

[15] Vancouver Gen Hosp, Vancouver, BC, Canada

[16] Johns Hopkins Univ, Sch Med, Baltimore, MD USA

[17] Univ Miami, Miller Sch Med, Miller Sch Med, Sarcoma Biol Lab,Miller Sch Med, Miami, FL 33136 USA

[18] Univ Calif Los Angeles, Los Angeles, CA USA

[19] Duke Univ, Sch Med, Dept Neurosurg, Durham, NC USA

来源：

GLOBAL SPINE JOURNAL | 2025年 / 15卷 / 1_SUPPL期

关键词：

spine; oncology; targeted therapy; chordoma; chondrosarcoma; malignant tumor; IMATINIB MESYLATE; LOCAL RECURRENCE; NUCLEAR EXPORT; SINGLE-ARM; PHASE-II; SARCOMA; EXPRESSION; INHIBITION; BRACHYURY; CYCLOPHOSPHAMIDE;

D O I：

10.1177/21925682241227917

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Study DesignSystematic review.ObjectivesThe objective of this review paper was to summarize targeted molecular therapy options for spinal chordoma and chondrosarcoma, and to provide an update on the relevant clinical trials open for recruitment.MethodsA systematic review of the current literature was performed, according to PRISMA guidelines, to summarize the latest developments in non-surgical molecular treatment options for low grade malignant primary spinal tumours. We also summarize those actively recruiting clinical trials based on clinicaltrials.gov.ResultsA total of 73 studies and completed clinical trials were reviewed. Twenty actively recruiting clinical trials (eight for chordoma and twelve for chondrosarcoma) were identified.ConclusionsThere is a strong need to find new therapeutic options to complement surgical resection and radiation therapy, which remain the cornerstone of management. Targeted therapies against molecular pathways show promise as compared to conventional chemotherapy.

引用

页码：120S / 131S

页数：12

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