Glycolysis in asthma: Its role and potential as a diagnostic or therapeutic target

Asthma is a heterogeneous disease characterized by chronic airway inflammation and hyperresponsiveness. A number of immune cells are involved in asthma pathogenesis, such as eosinophils, mast cells, T lymphocytes and neutrophils, as well as airway epithelial cells. Glycolysis plays a crucial role in glucose metabolism, and serves as a bridge between metabolic and inflammatory dysfunction. Research has found that abnormal glycolytic metabolism in various immune cells may contribute to the pathogenesis of asthma by inducing dysregulation in congenital and adaptive immune responses. Therefore, the inhibition of glycolysis can be a viable approach to prevent airway inflammation in asthma. The present study reviews the relationship between glycolysis and inflammatory cells in different asthma subtypes, and its potential therapeutic significance.