EFFECT OF PHENYTOIN ON PROTEIN-BINDING OF VALPROIC ACID

被引：4
|
作者：
BRUNI, J
GALLO, JM
WILDER, BJ
机构：
[1] UNIV FLORIDA, COLL MED, DEPT NEUROL, GAINESVILLE, FL 32611 USA
[2] UNIV FLORIDA, COLL PHARM, GAINESVILLE, FL 32611 USA
来源：
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES | 1979年 / 6卷 / 04期
关键词：
D O I：
10.1017/S0317167100023878
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
In vitro experiments using the equilibrium dialysis technique were performed to determine the binding of valproic acid to plasma components in the absence and presence of therapeutic concentrations of phenytoin. The free fraction of valproic acid was dependent on the total valproic acid concentration. Phenytoin did not influence valproic acid protein binding.
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页码：453 / 454
页数：2
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