Testosterone Treatment and Sexual Function in Men: Secondary Analysis of the T4DM (Testosterone for Diabetes) Trial

被引：1

作者：

Wittert, Gary A. ^{[1
,2
]}

Robledo, Kristy P. ^{[3
]}

Handelsman, David J. ^{[4
,5
]}

Inder, Warrick J. ^{[6
,7
]}

Stuckey, Bronwyn G. A. ^{[8
,9
]}

Yeap, Bu B. ^{[10
,11
]}

Bracken, Karen ^{[12
]}

Allan, Carolyn A. ^{[13
,14
]}

Jesudason, David ^{[1
,2
]}

Jenkins, Alicia ^{[15
]}

Januszewski, Andrzej S. ^{[16
]}

Grossmann, Mathis ^{[17
,18
]}

机构：

[1] Univ Adelaide, Freemasons Ctr Male Hlth & Wellbeing, Adelaide, SA 5000, Australia

[2] Queen Elizabeth Hosp, Dept Endocrinol, Adelaide, SA 5011, Australia

[3] Univ Sydney, NHMRC Clin Trials Ctr, Sydney, NSW 2050, Australia

[4] Univ Sydney, ANZAC Res Inst, Sydney, NSW 2139, Australia

[5] Concord Hosp, Dept Androl, Sydney, NSW 2139, Australia

[6] Princess Alexandra Hosp, Dept Endocrinol, Brisbane, Qld 4102, Australia

[7] Univ Queensland, Brisbane, Qld 4102, Australia

[8] Univ Western Australia, Sir Charles Gairdner Hosp, Keogh Inst Med Res, Dept Endocrinol & Diabet, Nedlands, WA 6009, Australia

[9] Univ Western Australia, Med Sch, Nedlands, WA 6009, Australia

[10] Univ Western Australia, Med Sch, Perth, WA 6150, Australia

[11] Fiona Stanley Hosp, Dept Endocrinol & Diabet, Perth, WA 6150, Australia

[12] Univ Sydney, Fac Med & Hlth, Sydney Musculoskeletal Hlth, Camperdown, NSW 2050, Australia

[13] Monash Univ, Hudson Inst Med Res, Ctr Endocrinol & Metab, Sch Clin Sci,Monash Hlth, Clayton, Vic 3168, Australia

[14] Monash Univ, Fac Med Nursing & Hlth Sci, Clayton, Vic 3168, Australia

[15] Baker Heart & Diabet Inst, Diabet & Vasc Med, Melbourne, Vic 3074, Australia

[16] Univ Sydney, Fac Med & Hlth, Sydney Sch Pharm, Canperdown, NSW 2050, Australia

[17] Austin Hlth, Dept Med & Endocrinol, Heidelberg, Vic 3079, Australia

[18] Univ Melbourne, Heidelberg, Vic 3079, Australia

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 2025年 / 110卷 / 07期

基金：

英国医学研究理事会;

关键词：

testosterone; sexual function; diabetes; obesity; clinical trial; URINARY-TRACT SYMPTOMS; LOW-ENERGY DIET; ERECTILE FUNCTION; OLDER MEN; INTERNATIONAL INDEX; HYPOGONADISM; DYSFUNCTION; METAANALYSIS; REPLACEMENT; HORMONES;

D O I：

10.1210/clinem/dgaf060

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Context The combined effects of testosterone treatment and lifestyle intervention on sexual function in men at high risk of type 2 diabetes are unclear.Objective To assess the effect of testosterone treatment with a lifestyle intervention in men aged 50 to 74 years at high risk of, or newly diagnosed with, type 2 diabetes (via oral glucose tolerance test).Design A secondary analysis of the Testosterone for the Prevention of Type 2 Diabetes trial, a double-blind, placebo-controlled trial conducted across 6 Australian centers.Interventions Intramuscular testosterone undecanoate (1000 mg) or placebo, 3 monthly for 2 years alongside a community-based lifestyle program.Main outcomes Sexual function measured using the International Index of Erectile Function (IIEF)-15 questionnaire.Results Of 1007 participants, 792 (79%) had complete International Index of Erectile Function-15 data. Baseline domain scores were inversely related to age and waist circumference, but unrelated to serum testosterone or estradiol levels. Testosterone treatment improved all 5 International Index of Erectile Function-15 domain scores, with stronger effects on sexual desire and orgasmic function in older men, and sexual desire in men with higher depression scores. Testosterone had no impact on depression. Independent of treatment, reductions in waist circumference were associated with improved erectile function, and reductions in depression scores correlated with better sexual function. Clinically significant improvement in erectile function and sexual desire occurred in 3% and 10% of men, respectively, and was inversely related to baseline function. Clinically significant improvement improvements in erectile function and sexual desire were greater in younger and older men respectively.Conclusion Testosterone treatment enhanced sexual desire and, to a lesser extent, erectile function, particularly in older men and those with higher waist circumference or depressive symptoms. Reduced waist circumference and depression independently improved sexual function.

引用

页码：e2157 / e2170

页数：14

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