Long-Term Response of Lorlatinib to Leptomeningeal Metastasis in Patients with Anaplastic Lymphoma Kinase Fusion Positive Non-Small Lung Cancer: A Case Report

被引：0

作者：

Fujiwara, Yutaka ^{[1
]}

Masago, Katsuhiro ^{[2
]}

Matsuzawa, Reiko ^{[1
]}

Yamaguchi, Teppei ^{[1
]}

Watanabe, Naohiro ^{[1
]}

Shimizu, Junichi ^{[1
]}

Sasaki, Eiichi ^{[2
]}

Horio, Yoshitsugu ^{[1
]}

机构：

[1] Aichi Canc Ctr, Dept Thorac Oncol, Nagoya, Aichi, Japan

[2] Aichi Canc Ctr, Dept Pathol & Mol Diag, Nagoya, Aichi, Japan

来源：

CASE REPORTS IN ONCOLOGY | 2024年 / 17卷 / 01期

关键词：

Anaplastic lymphoma kinase fusion; Leptomeningeal metastasis; Lorlatinib; Non-small cell lung cancer; BRAIN METASTASES; ALK; SAFETY; BRIGATINIB; CRIZOTINIB; INHIBITOR;

D O I：

10.1159/000540445

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Introduction: Patients with anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC) are at increased risk of central nervous system (CNS) metastasis at initial diagnosis and throughout treatment. In a phase 3 trial, lorlatinib, a third-generation ALK tyrosine kinase inhibitor, significantly improved progression-free survival. In further analysis, lorlatinib revealed superior intracranial efficacy and prolonged time to intracranial progression compared with crizotinib. Case Presentation: Herein, we report a case of ALK-positive NSCLC with leptomeningeal metastasis that was successfully treated with lorlatinib after progression to brigatinib and alectinib. This case demonstrates the potential of lorlatinib in managing leptomeningeal metastasis in ALK-positive NSCLC. Conclusion: The case suggests a paradigm shift in therapeutic approaches for CNS metastasis, including brain and leptomeningeal metastases. (c) 2024 The Author(s). Published by S. Karger AG, Basel

引用

页码：942 / 949

页数：8

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