Effect of Genetic Risk on the Relationship Between rs-fMRI Complexity and Tau and Amyloid PET in Alzheimer's Disease

被引：1

作者：

Jann, Kay ^{[1
,3
]}

Cen, Steven ^{[2
]}

Santos, Mariella ^{[1
]}

Aksman, Leon ^{[1
]}

Wijesinghe, Dilmini ^{[1
]}

Zhang, Ru ^{[1
]}

Lynch, Kirsten ^{[1
]}

Ringman, John M. ^{[2
]}

Wang, Danny J. ^{[1
]}

机构：

[1] Univ Southern Calif, USC Stevens Neuroimaging & Informat Inst, Keck Sch Med, Los Angeles, CA USA

[2] Univ Southern Calif, Keck Sch Med, Dept Neurol, Los Angeles, CA USA

[3] Univ Southern Calif, USC Stevens Neuroimaging & Informat Inst, Keck Sch Med USC, 2025 Zonal Ave, Los Angeles, CA 90033 USA

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2024年 / 101卷 / 02期

关键词：

Alzheimer's disease; amyloid; APOE; fMRI-complexity; tau; PATHOLOGY; APOE4; BETA; NEURODEGENERATION;

D O I：

10.3233/JAD-240459

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Reduced functional magnetic resonance imaging (fMRI)-complexity in Alzheimer's disease (AD) progression has been demonstrated and found to be associated with tauopathy and cognition. However, association of fMRI-complexity with amyloid and influence of genetic risk (APOE epsilon 4) remain unknown. Here we investigate the association between fMRI-complexity, tau-PET, and amyloid-PET as well as influence of APOE genotype using multivariate generalized linear models. We show that fMRI-complexity has a strong association with tau but not amyloid deposition and that the presence of an APOE epsilon 4 allele enhances this effect. Thus fMRI-complexity provides a surrogate marker of impaired brain functionality in AD progression.

引用

页码：429 / 435

页数：7

共 33 条

[1] Effect of APOE ε4 genotype on amyloid-β and tau accumulation in Alzheimer's disease
Baek, Min Seok
Cho, Hanna
Lee, Hye Sun
Lee, Jae Hoon
Ryu, Young Hoon
Lyoo, Chul Hyoung
[J]. ALZHEIMERS RESEARCH & THERAPY, 2020, 12 (01)
[2] Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer's disease
Bejanin, Alexandre
Schonhaut, Daniel R.
La Joie, Renaud
Kramer, Joel H.
Baker, Suzanne L.
Sosa, Natasha
Ayakta, Nagehan
Cantwell, Averill
Janabi, Mustafa
Lauriola, Mariella
O'Neil, James P.
Gorno-Tempini, Maria L.
Miller, Zachary A.
Rosen, Howard J.
Miller, Bruce L.
Jagust, William J.
Rabinovici, Gil D.
[J]. BRAIN, 2017, 140 : 3286 - 3300
[3] Amyloid-β and Tau The Trigger and Bullet in Alzheimer Disease Pathogenesis
Bloom, George S.
[J]. JAMA NEUROLOGY, 2014, 71 (04) : 505 - 508
[4] Multiscale entropy analysis of complex physiologic time series
Costa, M
Goldberger, AL
Peng, CK
[J]. PHYSICAL REVIEW LETTERS, 2002, 89 (06) : 1 - 068102
[5] Complexity and schizophrenia
Fernandez, Alberto
Gomez, Carlos
Hornero, Roberto
Jose Lopez-Ibor, Juan
[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2013, 45 : 267 - 276
[6] The association of APOE ε4 with cognitive function over the adult life course and incidence of dementia: 20years follow-up of the Whitehall II study
Gharbi-Meliani, Amin
Dugravot, Aline
Sabia, Severine
Regy, Melina
Fayosse, Aurore
Schnitzler, Alexis
Kivimaki, Mika
Singh-Manoux, Archana
Dumurgier, Julien
[J]. ALZHEIMERS RESEARCH & THERAPY, 2021, 13 (01)
[7] Alzheimer disease therapy-moving from amyloid-β to tau
Giacobini, Ezio
Gold, Gabriel
[J]. NATURE REVIEWS NEUROLOGY, 2013, 9 (12) : 677 - 686
[8] Default Mode Network Complexity and Cognitive Decline in Mild Alzheimer's Disease
Grieder, Matthias
Wang, Danny J. J.
Dierks, Thomas
Wahlund, Lars-Olof
Jann, Kay
[J]. FRONTIERS IN NEUROSCIENCE, 2018, 12
[9] FMRI Complexity Correlates with Tau-PET and Cognitive Decline in Late-Onset and Autosomal Dominant Alzheimer's Disease
Jann, Kay
Boudreau, Julia
Albrecht, Daniel
Cen, Steven Y.
Cabeen, Ryan P.
Ringman, John M.
Wang, Danny J. J.
[J]. JOURNAL OF ALZHEIMERS DISEASE, 2023, 95 (02) : 437 - 451
[10] Kay J., 2022, Complexity Toolbox 2.0

← 1 2 3 4 →