Postoperative complications of anterior cervical discectomy and fusion: A comprehensive systematic review and meta-analysis

被引：1

作者：

Tavanaei, Roozbeh ^{[1
]}

Ansari, Ali ^{[2
]}

Hatami, Amirali ^{[3
,4
]}

Heidari, Mohammad Javad ^{[2
]}

Dehghani, Mohammadreza ^{[5
]}

Hajiloo, Ahmad ^{[4
]}

Khorasanizadeh, Mirhojjat ^{[6
]}

Margetis, Konstantinos ^{[6
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Funct Neurosurg Res Ctr, Shohada Tajrish Neurosurg Ctr Excellence, Tehran, Iran

[2] Shiraz Univ Med Sci, Student Res Comm, Shiraz, Iran

[3] Shiraz Univ Med Sci, Inst Hlth, Hlth Policy Res Ctr, Shiraz, Iran

[4] Lorestan Univ Med Sci, Student Res Comm, Khorramabad, Iran

[5] Fasa Univ Med Sci, Student Res Comm, Fasa, Iran

[6] Mt Sinai Hosp, Icahn Sch Med, Dept Neurosurg, 1 Gustave L. Levy Pl, New York, NY 10029 USA

来源：

NORTH AMERICAN SPINE SOCIETY JOURNAL | 2025年 / 21卷

关键词：

Anterior cervical discectomy and fusion; Meta-analysis; Cervical spine; Spinal surgery; Spine; Fusion; Complication; Safety; SPINE-SURGERY; INTERBODY FUSION; NATIONAL TRENDS; RISK-FACTORS; SUBSIDENCE; OUTCOMES;

D O I：

10.1016/j.xnsj.2025.100596

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Anterior cervical discectomy and fusion (ACDF) is one of the most frequently performed spine procedures for different indications in the cervical spine. Various postoperative complications have been reported following the ACDF. This systematic review and meta-analysis aimed to calculate the incidence rate of different postoperative complications associated with ACDF surgery and also identify underlying risk factors for each complication. Methods: A systematic review of the literature was performed in PubMed/MEDLINE, Embase, and the Cochrane Library for observational studies published between January 1996 and March 2023 and reporting postoperative complications associated with ACDF. Randomized controlled trials and interventional investigations were not included in this study. Meta-regression was also performed using generalized linear mixed models with a binomial probability distribution on various potential predicting factors. Results: A total of 222 studies reporting the rate of complications associated with ACDF in 50,584 patients were included in the present study. The overall postoperative complication rate was 16%. The most common complications were excessive neck swelling (11.3%), pseudarthrosis (10.0%), dysphagia (9.5%), cage/graft subsidence (9.4%), worsening myelopathy (7.7%), and hoarseness (2.3%). The rate of nonhome discharge, readmission, and mortality were 13.8%, 3.7%, and 0.1% respectively. Based on meta-regression, more levels of fusion and increased age were significantly associated with an increase in the pooled overall postoperative complication rate. Moreover, the rate of some postoperative complications was significantly associated with a number of perioperative characteristics. Conclusions: To our knowledge, this study has been the most extensive meta-analysis conducted on the existing literature regarding ACDF-related complications and potential risk factors. However, future high-quality prospective studies or clinical trials are highly required to provide further evidence and also validate the present findings.

引用

页数：11

共 42 条

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