The ultimate microbial composition for correcting Th17/Treg cell imbalance and lipid metabolism disorders in osteoporosis

被引：0

作者：

An, Fangyu ^{[3
]}

Jia, Xueru ^{[2
]}

Shi, Yangyang ^{[2
]}

Xiao, Xiaolong ^{[1
]}

Yang, Fan ^{[1
]}

Su, Junchang ^{[2
]}

Peng, Xia ^{[1
]}

Geng, Guangqin ^{[2
]}

Yan, Chunlu ^{[1
]}

机构：

[1] Gansu Univ Chinese Med, Sch Trad Chinese & Werstern Med, Lanzhou 730000, Gansu, Peoples R China

[2] Gansu Univ Chinese Med, Sch Basic Med, Lanzhou 730000, Gansu, Peoples R China

[3] Gansu Univ Chinese Med, Teaching Expt Training Ctr, Lanzhou 730000, Gansu, Peoples R China

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2025年 / 144卷

基金：

中国国家自然科学基金;

关键词：

Intestinal microbiota; Immune regulation; Lipid metabolism; Osteoporosis; BONE-MINERAL DENSITY; MESENCHYMAL STEM-CELLS; GROWTH-FACTOR-I; BILE-SALT BIOTRANSFORMATIONS; IGF-BINDING PROTEINS; REGULATORY T-CELLS; VITAMIN-D-RECEPTOR; GUT MICROBIOTA; OSTEOBLAST DIFFERENTIATION; POSTMENOPAUSAL WOMEN;

D O I：

10.1016/j.intimp.2024.113613

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Osteoporosis is a systemic bone disease characterised by decreased bone mass and a deteriorated bone microstructure, leading to increased bone fragility and fracture risk. Disorders of the intestinal microbiota may be key inducers of osteoporosis. Furthermore, such disorders may contribute to osteoporosis by influencing immune function and lipid metabolism. Therefore, in this review, we aimed to summarise the molecular mechanisms through which the intestinal microbiota affect the onset and development of osteoporosis by regulating Th17/ Treg imbalance and lipid metabolism disorders. We also discussed the regulatory mechanisms underlying the effect of intestinal microbiota-related modulators on Th17/Treg imbalance and lipid metabolism disorders in osteoporosis, to explore new molecular targets for its treatment and provide a theoretical basis for clinical management.

引用

页数：22

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