TRPV1: The key bridge in neuroimmune interactions

被引：2

作者：

Chen, Jianwei ^{[1
]}

Sun, Wenqian ^{[1
]}

Zhu, Youjia ^{[1
]}

Zhao, Feng ^{[1
]}

Deng, Shuixiang ^{[1
]}

Tian, Mi ^{[1
]}

Wang, Yao ^{[1
]}

Gong, Ye ^{[1
]}

机构：

[1] Fudan Univ, Huashan Hosp, Dept Crit Care Med, 12 Wulumuqi Zhonglu, Shanghai 200040, Peoples R China

来源：

JOURNAL OF INTENSIVE MEDICINE | 2024年 / 4卷 / 04期

关键词：

TRPV1; Neuroimmune interaction; Immune system; Nervous system; GENE-RELATED PEPTIDE; RECEPTOR POTENTIAL VANILLOID-1; ACTIVATED ION-CHANNEL; SENSORY NEURONS; INFLAMMATORY RESPONSE; CAPSAICIN RECEPTOR; NERVOUS-SYSTEM; DENDRITIC CELL; UP-REGULATION; SUBSTANCE-P;

D O I：

10.1016/j.jointm.2024.01.008

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

The nervous and immune systems are crucial in fighting infections and inflammation and in maintaining immune homeostasis. The immune and nervous systems are independent, yet tightly integrated and coordinated organizations. Numerous molecules and receptors play key roles in enabling communication between the two systems. Transient receptor potential vanilloid subfamily member 1 (TRPV1) is a non-selective cation channel, recently shown to be widely expressed in the neuroimmune axis and implicated in neuropathic pain, autoimmune disorders, and immune cell function. TRPV1 is a key bridge in neuroimmune interactions, allowing for smooth convenient communication between the two systems. Here, we discuss the coordinated cross-talking between the immune and nervous systems and the functional role and the functioning manner of the TRPV1 involved. We suggest that TRPV1 provides new insights into the collaborative relationship between the nervous and mune systems, highlighting exciting opportunities for advanced therapeutic approaches to treating neurogenic inflammation and immune-mediated diseases.

引用

页码：442 / 452

页数：11