LncRNAs and the cancer epigenome: Mechanisms and therapeutic potential

被引：4
作者：
Nadhan, Revathy [1 ]
Isidoro, Ciro [2 ]
Song, Yong Sang [3 ]
Dhanasekaran, Danny N. [1 ,4 ]
机构：
[1] Univ Oklahoma Hlth Sci Ctr, Stephenson Canc Ctr, Oklahoma City, OK 73104 USA
[2] Univ Piemonte Orientale, Dept Hlth Sci, Lab Mol Pathol & Nanobioimaging, Novara, Italy
[3] Seoul Natl Univ, Coll Med, Dept Obstet & Gynecol, Canc Res Inst, Seoul 151921, South Korea
[4] Univ Oklahoma Hlth Sci Ctr, Dept Cell Biol, Oklahoma City, OK USA
来源：
CANCER LETTERS | 2024年 / 605卷
基金：
美国国家卫生研究院;
关键词：
Long non-coding RNAs (lncRNAs); Cancer epigenetics; DNA methylation; Histone modification; Chromatin remodeling; Oncogenes; Tumor suppressors; Epigenetic therapy; Precision oncology; RNA interference (RNAi); LONG NONCODING RNA; ACTIVE DNA DEMETHYLATION; EPITHELIAL-MESENCHYMAL PLASTICITY; HISTONE LYSINE METHYLTRANSFERASES; CHROMATIN-REMODELING COMPLEXES; CPG BINDING-PROTEINS; EPIGENETIC REGULATION; FREQUENT MUTATIONS; ESOPHAGEAL CANCER; PRC2; RECRUITMENT;
D O I：
10.1016/j.canlet.2024.217297
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Long non-coding RNAs (lncRNAs) have emerged as critical regulators of epigenome, modulating gene expression through DNA methylation, histone modification, and/or chromosome remodeling. Dysregulated lncRNAs act as oncogenes or tumor suppressors, driving tumor progression by shaping the cancer epigenome. By interacting with the writers, readers, and erasers of the epigenetic script, lncRNAs induce epigenetic modifications that bring about changes in cancer cell proliferation, apoptosis, epithelial-mesenchymal transition, migration, invasion, metastasis, cancer stemness and chemoresistance. This review analyzes and discusses the multifaceted role of lncRNAs in cancer pathobiology, from cancer genesis and progression through metastasis and therapy resistance. It also explores the therapeutic potential of targeting lncRNAs through innovative diagnostic, prognostic, and therapeutic strategies. Understanding the dynamic interplay between lncRNAs and epigenome is crucial for developing personalized therapeutic strategies, offering new avenues for precision cancer medicine.
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页数：18
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