LncRNAs and the cancer epigenome: Mechanisms and therapeutic potential

被引：4
作者：
Nadhan, Revathy [1 ]
Isidoro, Ciro [2 ]
Song, Yong Sang [3 ]
Dhanasekaran, Danny N. [1 ,4 ]
机构：
[1] Univ Oklahoma Hlth Sci Ctr, Stephenson Canc Ctr, Oklahoma City, OK 73104 USA
[2] Univ Piemonte Orientale, Dept Hlth Sci, Lab Mol Pathol & Nanobioimaging, Novara, Italy
[3] Seoul Natl Univ, Coll Med, Dept Obstet & Gynecol, Canc Res Inst, Seoul 151921, South Korea
[4] Univ Oklahoma Hlth Sci Ctr, Dept Cell Biol, Oklahoma City, OK USA
来源：
CANCER LETTERS | 2024年 / 605卷
基金：
美国国家卫生研究院;
关键词：
Long non-coding RNAs (lncRNAs); Cancer epigenetics; DNA methylation; Histone modification; Chromatin remodeling; Oncogenes; Tumor suppressors; Epigenetic therapy; Precision oncology; RNA interference (RNAi); LONG NONCODING RNA; ACTIVE DNA DEMETHYLATION; EPITHELIAL-MESENCHYMAL PLASTICITY; HISTONE LYSINE METHYLTRANSFERASES; CHROMATIN-REMODELING COMPLEXES; CPG BINDING-PROTEINS; EPIGENETIC REGULATION; FREQUENT MUTATIONS; ESOPHAGEAL CANCER; PRC2; RECRUITMENT;
D O I：
10.1016/j.canlet.2024.217297
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Long non-coding RNAs (lncRNAs) have emerged as critical regulators of epigenome, modulating gene expression through DNA methylation, histone modification, and/or chromosome remodeling. Dysregulated lncRNAs act as oncogenes or tumor suppressors, driving tumor progression by shaping the cancer epigenome. By interacting with the writers, readers, and erasers of the epigenetic script, lncRNAs induce epigenetic modifications that bring about changes in cancer cell proliferation, apoptosis, epithelial-mesenchymal transition, migration, invasion, metastasis, cancer stemness and chemoresistance. This review analyzes and discusses the multifaceted role of lncRNAs in cancer pathobiology, from cancer genesis and progression through metastasis and therapy resistance. It also explores the therapeutic potential of targeting lncRNAs through innovative diagnostic, prognostic, and therapeutic strategies. Understanding the dynamic interplay between lncRNAs and epigenome is crucial for developing personalized therapeutic strategies, offering new avenues for precision cancer medicine.
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页数：18
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共 285 条
  • [11] Histone Modifications and Cancer
    Audia, James E.
    Campbell, Robert M.
    [J]. COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2016, 8 (04):
  • [12] ISWI chromatin remodeling complexes in the DNA damage response
    Aydin, Ozge Z.
    Vermeulen, Wim
    Lans, Hannes
    [J]. CELL CYCLE, 2014, 13 (19) : 3016 - 3025
  • [13] Telomeric repeat-containing RNA and RNA surveillance factors at mammalian chromosome ends
    Azzalin, Claus M.
    Reichenbach, Patrick
    Khoriauli, Lela
    Giulotto, Elena
    Lingner, Joachim
    [J]. SCIENCE, 2007, 318 (5851) : 798 - 801
  • [14] Methyl-CpG binding proteins identify novel sites of epigenetic inactivation in human cancer
    Ballestar, E
    Paz, MF
    Valle, L
    Wei, S
    Fraga, MF
    Espada, J
    Cigudosa, JC
    Huang, THM
    Esteller, M
    [J]. EMBO JOURNAL, 2003, 22 (23) : 6335 - 6345
  • [15] Isolation of Chromatin from Dysfunctional Telomeres Reveals an Important Role for Ring1b in NHEJ-Mediated Chromosome Fusions
    Bartocci, Cristina
    Diedrich, Jolene K.
    Ouzounov, Iliana
    Li, Julia
    Piunti, Andrea
    Pasini, Diego
    Yates, John R., III
    Denchi, Eros Lazzerini
    [J]. CELL REPORTS, 2014, 7 (04): : 1320 - 1332
  • [16] Beltran M., 2019, G-Tract RNA Removes Polycomb Repressive Complex 2 from Genes, V26, P899
  • [17] Bhattacharjee D., 2016, Scientifica, V2016
  • [18] Epigenetic tools (The Writers, The Readers and The Erasers) and their implications in cancer therapy
    Biswas, Subhankar
    Rao, C. Mallikarjuna
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2018, 837 : 8 - 24
  • [19] Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation
    Blackledge, Neil P.
    Farcas, Anca M.
    Kondo, Takashi
    King, Hamish W.
    McGouran, Joanna F.
    Hanssen, Lars L. P.
    Ito, Shinsuke
    Cooper, Sarah
    Kondo, Kaori
    Koseki, Yoko
    Ishikura, Tomoyuki
    Long, Hannah K.
    Sheahan, Thomas W. p
    Brockdorff, Neil
    Kessler, Benedikt M.
    Koseki, Haruhiko
    Klose, Robert J.
    [J]. CELL, 2014, 157 (06) : 1445 - 1459
  • [20] The role of Xist-mediated Polycomb recruitment in the initiation of X-chromosome inactivation
    Bousard, Aurelie
    Raposo, Ana Claudia
    Zylicz, Jan Jakub
    Picard, Christel
    Pires, Vanessa Borges
    Qi, Yanyan
    Gil, Claudia
    Syx, Laurene
    Chang, Howard Y.
    Heard, Edith
    da Rocha, Simao Teixeira
    [J]. EMBO REPORTS, 2019, 20 (10)
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