Efficient synthesis of new isopavine alkaloids derived from (-)-reframidine and evaluation of their anti-proliferative effect against gastric cancer cells

被引：0

作者：

Pu, Liu-Yang ^{[1
,2
,3
,4
]}

Li, Limin ^{[2
,3
]}

Lv, Minling ^{[2
,3
]}

Li, Yan ^{[2
,3
]}

Ma, Min ^{[1
]}

Hu, Shengquan ^{[2
,3
]}

Wu, Zhengzhi ^{[2
,3
]}

机构：

[1] Jinan Univ, Integrated Chinese & Western Med, Postdoctoral Res Stn, Guangzhou, Peoples R China

[2] Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Shenzhen Inst Translat Med, Shenzhen, Peoples R China

[3] Shenzhen Inst Geriatr, Shenzhen, Peoples R China

[4] Xiangnan Univ, Sch Pharm, Chenzhou, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2024年

关键词：

Isopavine alkaloid; antiproliferation; gastric cancer cell; apoptosis;

D O I：

10.1080/14786419.2024.2431991

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A novel series of isopavine alkaloid reframidine with different substituent groups on the benzyl group of nitrogen was synthesised based on our reported enantioselective total synthesis route. These reframidine derivatives, 3b in particular, were found to provide anti-proliferative and pro-apoptotic activity against gastric cancer cells, which broadened the bioactivities beyond the traditional pharmacological neuroprotective properties of this kind of natural products.

引用

页数：8

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