Reduced CC Chemokine Receptor 4 Expression in Tumor Cells after Lenalidomide Treatment for Adult T-Cell Leukemia/Lymphoma: A Case Report

被引：0
|
作者：
Shimizu, Masatomo [1 ]
Yokote, Taiji [1 ]
Hatooka, Jun [1 ]
Kinoshita, Yuuki [1 ]
Imagawa, Akihisa [1 ]
Yasuda, Emi [2 ]
机构：
[1] Osaka Med & Pharmaceut Univ, Dept Internal Med, Takatsuki, Osaka, Japan
[2] Osaka Med & Pharmaceut Univ, Dept Pathol, Takatsuki, Osaka, Japan
来源：
CASE REPORTS IN ONCOLOGY | 2024年 / 17卷 / 01期
关键词：
Adult T-cell leukemia/lymphoma; CC chemokine receptor 4; Immunomodulatory drug; Lenalidomide; PROLIFERATION; AP-1;
D O I：
10.1159/000539122
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Introduction: CC chemokine receptor 4 (CCR4), which is involved in leukocyte migration, is expressed in most tumor cells in patients with adult T-cell leukemia/lymphoma (ATLL). Case Presentation: Here we report the case of a 78-year-old man diagnosed with lymphoma-type ATLL expressing CCR4. The patient was administered two cycles of lenalidomide but died because of sepsis 5 months after the initial diagnosis. Autopsy revealed ATLL cells at several sites. Immunohistochemical analysis revealed that these ATLL cells had reduced CCR4 expression. Conclusion: The present case suggests that treatment should be carefully determined in ATLL with reference to a history of lenalidomide use and CCR4 expression. (c) 2024 The Author(s). Published by S. Karger AG, Basel
引用
收藏
页码：602 / 607
页数：6
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