Reduced CC Chemokine Receptor 4 Expression in Tumor Cells after Lenalidomide Treatment for Adult T-Cell Leukemia/Lymphoma: A Case Report

被引：0

作者：

Shimizu, Masatomo ^{[1
]}

Yokote, Taiji ^{[1
]}

Hatooka, Jun ^{[1
]}

Kinoshita, Yuuki ^{[1
]}

Imagawa, Akihisa ^{[1
]}

Yasuda, Emi ^{[2
]}

机构：

[1] Osaka Med & Pharmaceut Univ, Dept Internal Med, Takatsuki, Osaka, Japan

[2] Osaka Med & Pharmaceut Univ, Dept Pathol, Takatsuki, Osaka, Japan

来源：

CASE REPORTS IN ONCOLOGY | 2024年 / 17卷 / 01期

关键词：

Adult T-cell leukemia/lymphoma; CC chemokine receptor 4; Immunomodulatory drug; Lenalidomide; PROLIFERATION; AP-1;

D O I：

10.1159/000539122

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Introduction: CC chemokine receptor 4 (CCR4), which is involved in leukocyte migration, is expressed in most tumor cells in patients with adult T-cell leukemia/lymphoma (ATLL). Case Presentation: Here we report the case of a 78-year-old man diagnosed with lymphoma-type ATLL expressing CCR4. The patient was administered two cycles of lenalidomide but died because of sepsis 5 months after the initial diagnosis. Autopsy revealed ATLL cells at several sites. Immunohistochemical analysis revealed that these ATLL cells had reduced CCR4 expression. Conclusion: The present case suggests that treatment should be carefully determined in ATLL with reference to a history of lenalidomide use and CCR4 expression. (c) 2024 The Author(s). Published by S. Karger AG, Basel

引用

页码：602 / 607

页数：6

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