Gene regulation and signaling transduction in mediating the self-renewal, differentiation, and apoptosis of spermatogonial stem cells

被引:1
作者
He, Cai-Mei [1 ,2 ,3 ]
Zhang, Dong [1 ,2 ,3 ]
He, Zuping [1 ,2 ,3 ]
机构
[1] Key Lab Model Anim & Stem Cell Biol Hunan Prov, Changsha 410013, Peoples R China
[2] Hunan Normal Univ, Engn Res Ctr Reprod & Translat Med Hunan Prov, Sch Med, Changsha 410013, Peoples R China
[3] Hunan Normal Univ, Manufacture Based Learning & Res Demonstrat Ctr Hu, Changsha 410013, Peoples R China
来源
ASIAN JOURNAL OF ANDROLOGY | 2025年 / 27卷 / 01期
关键词
fate decisions; gene regulation; male infertility; signaling transduction pathways; spermatogonial stem cells; EPIDERMAL-GROWTH-FACTOR; BCL-2 FAMILY PROTEINS; GERM-CELLS; NEUROTROPHIC FACTOR; UNDIFFERENTIATED SPERMATOGONIA; 1ST WAVE; C-KIT; TRANSCRIPTIONAL CONTROL; MALE-INFERTILITY; DNA-BINDING;
D O I
10.4103/aja202464
中图分类号
R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
摘要
Infertility has become one of the most serious diseases worldwide, and 50% of this disease can be attributed to male-related factors. Spermatogenesis, by definition, is a complex process by which spermatogonial stem cells (SSCs) self-renew to maintain stem cell population within the testes and differentiate into mature spermatids. It is of great significance to uncover gene regulation and signaling pathways that are involved in the fate determinations of SSCs with aims to better understand molecular mechanisms underlying human spermatogenesis and identify novel targets for gene therapy of male infertility. Significant achievement has recently been made in demonstrating the signaling molecules and pathways mediating the fate decisions of mammalian SSCs. In this review, we address key gene regulation and crucial signaling transduction pathways in controlling the self-renewal, differentiation, and apoptosis of SSCs, and we illustrate the networks of genes and signaling pathways in SSC fate determinations. We also highlight perspectives and future directions in SSC regulation by genes and their signaling pathways. This review could provide novel insights into the genetic regulation of normal and abnormal spermatogenesis and offer molecular targets to develop new approaches for gene therapy of male infertility.
引用
收藏
页码:4 / 12
页数:9
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