Persistent activity during working memory maintenance predicts long-term memory formation in the human hippocampus

被引:1
|
作者
Daume, Jonathan [1 ,2 ,3 ]
Kamin, Jan [4 ]
Salimpour, Yousef [5 ]
Schjetnan, Andrea Gomez Palacio [6 ]
Anderson, William S. [5 ]
Valiante, Taufik A. [6 ,7 ,8 ]
Mamelak, Adam N. [1 ]
Rutishauser, Ueli [1 ,2 ,3 ,8 ,9 ]
机构
[1] Cedars Sinai Med Ctr, Dept Neurosurg, Los Angeles, CA 90048 USA
[2] Cedars Sinai Med Ctr, Dept Neurol, Los Angeles, CA 90048 USA
[3] Cedars Sinai Med Ctr, Ctr Neural Sci & Med, Los Angeles, CA 90048 USA
[4] Polish Acad Sci, Nencki Inst Expt Biol, Ctr Excellence Neural Plast & Brain Disorders BRAI, PL-02093 Warsaw, Poland
[5] Johns Hopkins Sch Med, Dept Neurosurg, Baltimore, MD 21205 USA
[6] Univ Hlth Network, Krembil Res Inst, Toronto, ON M5T 2S8, Canada
[7] Univ Toronto, Dept Surg, Div Neurosurg, Toronto, ON M5T 1P5, Canada
[8] Univ Toronto, Inst Biomat & Biomed Engn, Dept Elect & Comp Engn, Toronto, ON M5S 3G9, Canada
[9] CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USA
关键词
SINGLE NEURONS; PREFRONTAL CORTEX; REPRESENTATION; INFORMATION; CONTRIBUTES; RETRIEVAL; NETWORKS; BRAIN;
D O I
10.1016/j.neuron.2024.09.013
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Working memory (WM) and long-term memory (LTM) are often viewed as separate cognitive systems. Little is known about how these systems interact when forming memories. We recorded single neurons in the human medial temporal lobe while patients maintained novel items in WM and completed a subsequent recognition memory test for the same items. In the hippocampus, but not in the amygdala, the level of WM content-selective persistent activity during WM maintenance was predictive of whether the item was later recognized with high confidence or forgotten. By contrast, visually evoked activity in the same cells was not predictive of LTM formation. During LTM retrieval, memory-selective neurons responded more strongly to familiar stimuli for which persistent activity was high while they were maintained in WM. Our study suggests that hippocampal persistent activity of the same cells supports both WM maintenance and LTM encoding, thereby revealing a common single-neuron component of these two memory systems.
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收藏
页数:16
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